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Synthetic 3D scaffolds for cancer immunotherapy.
Current Opinion in Biotechnology ( IF 7.1 ) Pub Date : 2019-12-12 , DOI: 10.1016/j.copbio.2019.11.010 Armand Kurum 1 , Min Gao 2 , Li Tang 3
Current Opinion in Biotechnology ( IF 7.1 ) Pub Date : 2019-12-12 , DOI: 10.1016/j.copbio.2019.11.010 Armand Kurum 1 , Min Gao 2 , Li Tang 3
Affiliation
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Recent clinical success of systemic cancer immunotherapy has paved the way for the next-generation therapeutics. Nevertheless, cancer immunotherapies, in particular combination therapies, are associated in some cases with severe side effects and low response rates. Synthetic scaffolds have emerged as a promising platform to deliver immunotherapeutic agents locally. Placed at strategic locations of the body, scaffolds can reduce side effects while increasing the concentration of the agent at the site of interest. Moreover, scaffolds can mimic the context, in which biochemical cues are presented in vivo to enhance cell modulation. Recent research has focused on designing three-dimensional (3D) scaffolds with specific properties to modulate the antitumor response at various stages of the cancer immunity cycle. As the number of immunotherapies in clinical trials is soaring, it is essential to critically evaluate the role that scaffolds can play in improving the safety and efficacy of existing and future therapies.
中文翻译：
用于癌症免疫治疗的合成3D支架。
系统性癌症免疫疗法的最新临床成功为下一代疗法铺平了道路。然而，在某些情况下，癌症免疫疗法，特别是联合疗法，具有严重的副作用和低应答率。合成支架已经成为将免疫治疗剂局部递送的有前途的平台。支架放置在人体的重要位置，可以减少副作用，同时增加目标部位药物的浓度。此外，支架可以模拟在体内呈现生化线索以增强细胞调节的环境。最近的研究集中在设计具有特定特性的三维（3D）支架上，以调节癌症免疫周期各个阶段的抗肿瘤反应。
更新日期：2020-04-20
中文翻译：
用于癌症免疫治疗的合成3D支架。
系统性癌症免疫疗法的最新临床成功为下一代疗法铺平了道路。然而，在某些情况下，癌症免疫疗法，特别是联合疗法，具有严重的副作用和低应答率。合成支架已经成为将免疫治疗剂局部递送的有前途的平台。支架放置在人体的重要位置，可以减少副作用，同时增加目标部位药物的浓度。此外，支架可以模拟在体内呈现生化线索以增强细胞调节的环境。最近的研究集中在设计具有特定特性的三维（3D）支架上，以调节癌症免疫周期各个阶段的抗肿瘤反应。
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