Albanitriles A-G: Antiprotozoal Polyacetylene Nitriles from a Mycale Marine Sponge.,Journal of Natural Products

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Albanitriles A-G: Antiprotozoal Polyacetylene Nitriles from a Mycale Marine Sponge.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2019-12-13 , DOI: 10.1021/acs.jnatprod.9b00840
Samuele Sala ₁ , Jane Fromont ₂ , Oliver Gomez ₂ , Daniel Vuong ₃ , Ernest Lacey ₃ , Gavin R Flematti ₁

Affiliation

Seven new nitrile-bearing polyacetylenes, named albanitriles A-G, were isolated from a marine sponge of the Mycale genus (Order: Poecilosclerida, Family: Mycalidae) collected near Albany, Western Australia. Structural elucidation was achieved using a combination of high-resolution mass spectrometry and ultraviolet/visible, infrared, and nuclear magnetic resonance spectroscopy. The compounds were found to possess moderate activity against Giardia duodenalis when compared to a metronidazole positive control.

中文翻译：

Albanitriles AG：来自Mycale Marine Sponge的抗原生动物性聚乙炔腈。

从西澳大利亚州奥尔巴尼附近收集的Mycale属海洋海绵（订购：Poecilosclerida，家庭：Mycalidae）中分离出七个新的含腈的聚乙炔，称为albanitriles AG。结构解析是通过高分辨率质谱与紫外/可见，红外和核磁共振波谱的结合来实现的。与甲硝唑阳性对照相比，发现该化合物对十二指肠贾第鞭毛虫具有中等活性。

更新日期：2019-12-13

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