High-order interactions distort the functional landscape of microbial consortia.,PLOS Biology

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High-order interactions distort the functional landscape of microbial consortia.
PLOS Biology ( IF 7.8 ) Pub Date : 2019-12-12 , DOI: 10.1371/journal.pbio.3000550
Alicia Sanchez-Gorostiaga _{1,

2} , Djordje Bajić _{1,

2} , Melisa L Osborne _{3,

4} , Juan F Poyatos _{3,

5} , Alvaro Sanchez _{1,

2,

3}

Affiliation

Understanding the link between community composition and function is a major challenge in microbial population biology, with implications for the management of natural microbiomes and the design of synthetic consortia. Specifically, it is poorly understood whether community functions can be quantitatively predicted from traits of species in monoculture. Inspired by the study of complex genetic interactions, we have examined how the amylolytic rate of combinatorial assemblages of six starch-degrading soil bacteria depend on the separate functional contributions from each species and their interactions. Filtering our results through the theory of biochemical kinetics, we show that this simple function is additive in the absence of interactions among community members. For about half of the combinatorially assembled consortia, the amylolytic function is dominated by pairwise and higher-order interactions. For the other half, the function is additive despite the presence of strong competitive interactions. We explain the mechanistic basis of these findings and propose a quantitative framework that allows us to separate the effect of behavioral and population dynamics interactions. Our results suggest that the functional robustness of a consortium to pairwise and higher-order interactions critically affects our ability to predict and bottom-up engineer ecosystem function in complex communities.

中文翻译：

高阶相互作用扭曲了微生物群落的功能景观。

了解群落组成和功能之间的联系是微生物种群生物学的一个主要挑战，对自然微生物组的管理和合成菌群的设计具有影响。具体来说，人们对是否可以根据单一栽培物种的特征定量预测群落功能知之甚少。受复杂遗传相互作用研究的启发，我们研究了六种淀粉降解土壤细菌组合组合的淀粉分解率如何取决于每个物种的单独功能贡献及其相互作用。通过生化动力学理论过滤我们的结果，我们发现这个简单的函数在群落成员之间没有相互作用的情况下是相加的。对于大约一半的组合组装的联合体，淀粉分解功能由成对和高阶相互作用主导。对于另一半，尽管存在强烈的竞争性相互作用，但该功能是可加的。我们解释了这些发现的机制基础，并提出了一个定量框架，使我们能够区分行为和群体动态相互作用的影响。我们的结果表明，联盟对成对和高阶相互作用的功能稳健性严重影响我们预测和自下而上设计复杂群落中生态系统功能的能力。

更新日期：2019-12-13

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