Transition-metal-free synthesis of CMe2CF3-containing chroman-4-ones via decarboxylative trifluoroalkylation,Organic Chemistry Frontiers

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Transition-metal-free synthesis of CMe2CF3-containing chroman-4-ones via decarboxylative trifluoroalkylation
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2019/12/12 , DOI: 10.1039/c9qo01283d
Miao-Chang Liu _{1,

2,

3,

4,

5} , Wei Liu _{5,

6,

7,

8} , Hua-Yue Wu _{5,

6,

7,

8} , Yun-Bing Zhou _{5,

6,

7,

8} , Qiuping Ding _{1,

2,

3,

4,

5} , Yiyuan Peng _{1,

2,

3,

4,

5}

Affiliation

(NH₄)₂S₂O₈-mediated decarboxylative trifluoroalkylation of alkenes with 3,3,3-trifluoro-2,2-dimethylpropanoic acid under metal-free conditions has been described. This approach provides a new pathway to directly synthesize a series of CMe₂CF₃-containing chroman-4-ones from simple chemical feedstocks. Particularly, the utility of the method was demonstrated by its application in the synthesis of CMe₂CF₃-derived TRPV1 precursors.

中文翻译：

通过脱羧三氟烷基化无过渡金属合成含CMe2CF3的苯并四氢吡喃

已经描述了在无金属条件下用（3,3,3-三氟-2,2-二甲基丙酸）（NH ₄）₂ S ₂ O ₈介导的烯烃的脱羧三氟烷基化。这种方法提供了一种从简单的化学原料直接合成一系列含CMe ₂ CF ₃的苯并二氢吡喃-4-酮的新途径。特别地，通过在合成CMe ₂ CF ₃衍生的TRPV1前体中的应用证明了该方法的实用性。

更新日期：2020-02-13

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