Soybean peptides Maillard reaction products (SMRPs) as a flavor enhancer were prepared to investigate its potential prebiotic activities on modulating gut microbiota to alleviate aging-related disorders in d-galactose-induced ICR mice. The mice were divided into six groups during 6 weeks experimental period, including normal control, natural aging control, d-galactose aging group, low, medium and high dose SMRPs groups (200, 400 and 800 mg/kg/day). Results showed that d-galactose aging mice with SMRPs administration had increased food intake, body weight, organ indexes, urine fluorescence intensity and feces color. Additionally, SMRPs could elevate richness and diversity of gut microbiota and ameliorate microbial community structure. The pathogenic bacteria was effectively suppressed while beneficial bacteria Lactobacillus and Bifidobacterium were promoted. Furthermore, oxidative stress, cognitive impairment and systemic inflammation were ameliorated after SMRPs administration due to gut microflora constitution and their metabolite alterations. Our results demonstrated that SMRPs might possess potential prebiotic activities to attenuate aging.

制备了大豆肽美拉德反应产物（SMRPs）作为增味剂，以研究其潜在的益生元活性，可调节肠道菌群以减轻d-半乳糖诱导的ICR小鼠的衰老相关疾病。在6周的实验期间，将小鼠分为六组，包括正常对照，自然衰老对照，d-半乳糖衰老组，低，中和高剂量SMRPs组（200、400和800mg / kg /天）。结果表明，d给予SMRP的半乳糖衰老小鼠的食物摄入量，体重，器官指数，尿液荧光强度和粪便颜色增加。此外，SMRPs可以提高肠道菌群的丰富性和多样性，并改善微生物群落结构。有效地抑制了病原细菌，同时促进了有益细菌乳杆菌和双歧杆菌。此外，由于肠道菌群的组成及其代谢物的改变，SMRPs给药后，氧化应激，认知障碍和全身性炎症得到改善。我们的结果表明，SMRPs可能具有潜在的益生元活性，以减弱衰老。