In this manuscript we have collected and organized some of the most salient and recent examples of chemical manipulations involving indole as an electrophilic partner in catalytic transformations. Indole continues to gain growing credits by the synthetic chemistry community due to the innate flexibility. In this context, the possibility to commutate its innate nucleophilic reactivity into an electrophilic profile is expanding significantly the scenario. Currently, new strategies have been developed towards this aim, with the possibility to implement catalytic and stereoselective variants mainly based on metal catalysis (copper) and organic catalysis (nucleophilic catalysis). After the initial critical review article published by the authors in the field (2013) the present monograph collects all the most recent and salient examples of catalytic nucleophilic manipulation of indoles with a particular emphasis on scope, limitations and mechanistic insights.

中文翻译：

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“亲电子”吲哚催化功能化的最新进展

在本手稿中，我们收集并整理了一些最重要的和最近的化学操作实例，涉及吲哚作为催化转化中的亲电子分子。由于天生的灵活性，吲哚继续在合成化学界获得越来越多的赞誉。在这种情况下，将其先天的亲核反应性转化为亲电性的可能性大大扩展了这种情况。当前，已针对该目标开发了新的策略，并有可能主要基于金属催化（铜）和有机催化（亲核催化）实施催化和立体选择变体。