The influence of the flow rate and the mode of mixing of reagent solutions on the result of glycosylation of isopropyl alcohol with glycooxazoline in 1,2-dichloroethane in the presence of (±)-camphor-10-sulfonic acid was studied. No reaction products were observed at low flow rates (⩽0.043 mL h−1) when using two Comet X-01 micromixers. Under these conditions, the disaggregation of supramers of the reagents is apparently inefficient for the reaction between them to occur. However, when one of the Comet X-01 micromixers was replaced with a T-shaped adapter (at the same flow rate), the expected reaction products, glycoside and glycal, appeared in the reaction mixture. This apparently suggests a higher disaggregation of the supramers reagents under these conditions, which allows the chemical reaction between them to occur.

中文翻译：

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流动中的糖基化：流速和混合器类型的影响

在(±)-樟脑-10-磺酸存在下，研究了流速和试剂溶液混合方式对1,2-二氯乙烷中异丙醇与羟基恶唑啉糖基化结果的影响。当使用两个 Comet X-01 微混合器时，在低流速 (⩽0.043 mL h-1) 下没有观察到反应产物。在这些条件下，试剂超聚体的解聚对于它们之间发生的反应显然是低效的。然而，当其中一台 Comet X-01 微混合器被替换为 T 形适配器（以相同的流速）时，预期的反应产物糖苷和糖醛出现在反应混合物中。这显然表明在这些条件下超聚体试剂的分解程度更高，这允许它们之间发生化学反应。