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Neuroprotective Effect of Citicoline Eye Drops on Corneal Sensitivity After LASIK.
Journal of Refractive Surgery ( IF 2.9 ) Pub Date : 2019-12-12 , DOI: 10.3928/1081597x-20191021-01
Esat Cinar , Berna Yuce , Fatih Aslan , Gökhan Erbakan

Citicoline (cytidine-5-diphosphocholine), an intermediate product of phospholipid biosynthesis, is believed to be transformed to cytidine monophosphate and phosphocholine by phosphodiesterases in the cell wall and taken up into neuronal cells.1,2 In addition to the synthesis of acetylcholine, cells use choline as a precursor of certain phospholipids (eg, phosphocholine) that are major constituents of all biological membranes.2 Exogenous citicoline has been used as a therapeutic drug to treat central nervous system disorders including ischemic stroke and Parkinson's disease.3,4 Furthermore,

中文翻译:

LASIK后,Citicoline滴眼液对角膜敏感性的神经保护作用。

人们认为,磷脂生物合成的中间产物Citicoline(胞苷-5-二磷酸胆碱)通过细胞壁中的磷酸二酯酶转化为胞苷一磷酸和磷酸胆碱,并被吸收到神经元细胞中1,2。除了乙酰胆碱的合成外,细胞使用胆碱作为某些磷脂(例如,磷酸胆碱)的前体,这些磷脂是所有生物膜的主要成分。2外源胞二磷胆碱已被用作治疗中枢神经系统疾病(包括缺血性中风和帕金森氏病)的治疗药物。3,4此外,
更新日期:2019-12-13
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