The human induced pluripotent stem cell (iPSC) line YAHKMUi001-A was derived from the dermal fibroblasts of a patient with Tetralogy of Fallot (TOF), with a mutation in the TBX1 gene (c.928G > A). The skin fibroblasts were obtained from a 4-year-old boy, and were infected with Sendai virus expressing the Yamanaka factors. The YAHKMUi001-A iPSC line expresses pluripotent stem cell markers, displays a normal karyotype, and has the capacity to differentiate into 3 germ layers. This cell line model can be a good tool to study the pathological mechanism of the TBX1 gene mutations associated with TOF.

中文翻译：

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从法洛四联症（YAHKMUi001-A）携带TBX1基因突变的患者中产生人iPSC品系。

人诱导多能干细胞（iPSC）品系YAHKMUi001-A源自法洛四联症（TOF）患者的真皮成纤维细胞，其中TBX1基因发生突变（c.928G> A）。皮肤成纤维细胞取自一个四岁男孩，并被表达山中因子的仙台病毒感染。YAHKMUi001-A iPSC品系表达多能干细胞标记，显示正常的核型，并具有分化为3个胚层的能力。该细胞系模型可以作为研究与TOF相关的TBX1基因突变的病理机制的好工具。