A thermodynamically controlled and reversible nucleophilic addition of a monofluorinated sulfone, α-fluoro-α-phenylthio-α-phenylsulfonylmethane (FTSM), to aldehydes has been developed, which allows the efficient synthesis of β-fluorinated carbinols with high diastereoselectivity. Control experiments showed that the fluorine substitution not only promotes the addition process, but also improves the diastereoselectivity.

中文翻译：

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α-氟-α-苯硫基-α-苯磺酰基甲烷（FTSM）对醛的高度非对映选择性和热力学控制的亲核加成反应

已经开发了一种热力学控制和可逆的亲核加成法，将单氟化砜α-氟-α-苯硫基-α-苯基磺酰甲烷（FTSM）添加到醛中，从而可以高效合成具有高非对映选择性的β-氟化甲醇。对照实验表明，氟取代不仅促进了加成过程，而且提高了非对映选择性。