Damage to DNA is a central mechanism to the initiation of carcinogenesis. As a consequence, precise DNA damage detection is essential for an effective risk assessment of xenobiotics and constitutes a powerful tool for human biomonitoring and early stage cancer risk assessment. Here we highlight four innovative approaches for determining genotoxicity in a reliable and in the future high-throughput manner. In this context, we discuss and evaluate recent improvements to well-established methods and present promising new techniques.

中文翻译：

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可靠的高通量遗传毒性评估的创新技术和策略。

DNA的损伤是引发癌变的主要机制。因此，精确的DNA损伤检测对于有效评估异种生物风险至关重要，是构成人类生物监测和早期癌症风险评估的有力工具。在这里，我们重点介绍了四种以可靠的方式以及将来以高通量方式确定遗传毒性的创新方法。在这种情况下，我们讨论并评估了对完善方法的最新改进，并提出了有前途的新技术。