OBJECTIVES Gilles de la Tourette syndrome (GTS) is a neuropsychiatric condition characterized by motor and vocal tics. There is undoubtedly basal ganglia involvement, which are also important for cognitive processes including performance monitoring and interference resolution. We investigated these functions in adult patients with GTS compared to healthy controls (HCs). METHODS We compared a group of N = 23 adult patients with GTS to N = 27 HC on a flanker task during an EEG recording. Reaction times and error rates were recorded, as well as N2 and Ne/ERN amplitudes. The N2 is an index of interference resolution. The Ne/ERN is a negative fronto-central component, occurring when participants make mistakes. RESULTS Patients' reaction times were enhanced on incongruent trials compared to HC. Electrophysiological data revealed more frontal components, as well as significantly increased Ne/ERN amplitudes in patients with GTS compared to HC (p = 0.026). CONCLUSIONS Altered electrophysiological correlates of error processing in adult patients with GTS compared to HC cannot be attributed to differential error probabilities. Potentially, patients recruit compensatory resources from frontal networks to maintain behavioural performance. SIGNIFICANCE This study gives further insight into cognitive deficits of patients with GTS, and the underlying neural processes of these functions.

中文翻译：

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Gilles de la Tourette 综合征成年患者表现监测的神经相关性：事件相关电位的研究

目标 Gilles de la Tourette 综合征 (GTS) 是一种以运动和发声抽搐为特征的神经精神疾病。毫无疑问，基底神经节参与，这对认知过程也很重要，包括性能监测和干扰解决。与健康对照 (HC) 相比，我们研究了成年 GTS 患者的这些功能。方法 我们在 EEG 记录期间将一组 N = 23 名 GTS 成年患者与 N = 27 名 HC 的侧翼任务进行了比较。记录反应时间和错误率，以及 N2 和 Ne/ERN 振幅。N2是干扰分辨率的指标。Ne/ERN 是一个负面的前中枢成分，发生在参与者犯错时。结果 与 HC 相比，在不一致的试验中患者的反应时间得到了提高。电生理数据显示，与 HC 相比，GTS 患者的额叶成分更多，Ne/ERN 振幅显着增加（p = 0.026）。结论 与 HC 相比，成人 GTS 患者错误处理的电生理相关性改变不能归因于不同的错误概率。潜在地，患者从额叶网络招募补偿资源以维持行为表现。意义 本研究进一步了解 GTS 患者的认知缺陷，以及这些功能的潜在神经过程。结论 与 HC 相比，成人 GTS 患者错误处理的电生理相关性改变不能归因于不同的错误概率。潜在地，患者从额叶网络招募补偿资源以维持行为表现。意义 本研究进一步了解 GTS 患者的认知缺陷，以及这些功能的潜在神经过程。结论 与 HC 相比，成人 GTS 患者错误处理的电生理相关性改变不能归因于不同的错误概率。潜在地，患者从额叶网络招募补偿资源以维持行为表现。意义 本研究进一步了解 GTS 患者的认知缺陷，以及这些功能的潜在神经过程。