OBJECTIVE The pedunculopontine nucleus (PPN) has been proposed as a new deep brain stimulation (DBS) target for the treatment in idiopathic Parkinson's syndrome (IPS) and progressive supranuclear palsy (PSP). In IPS, levodopa has been shown to induce alpha activity in the PPN, indicating a possible physiological role for these oscillations in movement control. Despite shared clinical features, the PPN is more severely affected in PSP than IPS. Here we investigated neuronal oscillations in the PPN in PSP and the influence of levodopa and movement. METHODS Local field potentials were recorded bilaterally from the PPN of 4 PSP patients at rest, with levodopa and during self-paced leg movements. RESULTS During rest, levodopa administration was associated with significantly increased alpha and reduced gamma activity in the PPN. Without levodopa, continuous movements were associated with reduced alpha and beta power. These differences between oscillatory power during movement and resting state were not observed with levodopa administration. CONCLUSION In PSP the changes in neuronal oscillations in the PPN region on levodopa administration are similar to those reported in IPS. The enhancement of lower frequency oscillations in the PPN is possibly influenced by a dopaminergic activation of the striatal pathway and a reduced pallidal inhibition. SIGNIFICANCE Levodopa influences neuronal oscillations at low and high frequencies in the PPN region in Parkinsonian disorders.

中文翻译：

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进行性核上性麻痹中桥脚核的神经元振荡：左旋多巴和运动的影响

目的 桥脚核 (PPN) 已被提议作为一种新的脑深部刺激 (DBS) 靶点，用于治疗特发性帕金森综合征 (IPS) 和进行性核上性麻痹 (PSP)。在 IPS 中，左旋多巴已被证明可诱导 PPN 中的 α 活性，表明这些振荡在运动控制中可能具有生理作用。尽管有共同的临床特征，但 PSP 中 PPN 的影响比 IPS 更严重。在这里，我们研究了 PSP 中 PPN 中的神经元振荡以及左旋多巴和运动的影响。方法从 4 名 PSP 患者静息、左旋多巴和自控腿部运动期间的 PPN 双侧记录局部场电位。结果 在休息期间，左旋多巴给药与 PPN 中 α 活性显着增加和 γ 活性降低有关。没有左旋多巴，连续运动与 alpha 和 beta 功率降低有关。左旋多巴给药未观察到运动和静息状态期间振荡功率之间的这些差异。结论 在 PSP 中，左旋多巴给药后 PPN 区域神经元振荡的变化与 IPS 中报道的相似。PPN 中低频振荡的增强可能受到纹状体通路的多巴胺能激活和苍白球抑制降低的影响。意义 左旋多巴影响帕金森病 PPN 区域中低频和高频的神经元振荡。结论 在 PSP 中，左旋多巴给药后 PPN 区域神经元振荡的变化与 IPS 中报道的相似。PPN 中低频振荡的增强可能受到纹状体通路的多巴胺能激活和苍白球抑制降低的影响。意义 左旋多巴影响帕金森病 PPN 区域中低频和高频的神经元振荡。结论 在 PSP 中，左旋多巴给药后 PPN 区域神经元振荡的变化与 IPS 中报道的相似。PPN 中低频振荡的增强可能受到纹状体通路的多巴胺能激活和苍白球抑制降低的影响。意义 左旋多巴影响帕金森病 PPN 区域中低频和高频的神经元振荡。