Despite a robust design and good statistical power, the ISAACC study (Impact of Sleep Apnea syndrome in the evolution of Acute Coronary syndrome. Effect of intervention with CPAP), similar to the SAVE study (Sleep Apnea cardioVascular Endpoints), did not show a positive effect of obstructive sleep apnoea (OSA) treatment with continuous positive airway pressure (CPAP) as a secondary prevention for cardiovascular events. The modest but clinically similar use of CPAP (<3 h per night) observed in this study and in SAVE might explain, at least in part, this absence of an effect. However, when the authors compared participants with acute coronary syndrome (ACS) without OSA (reference group) with participants with ASC and OSA who were given usual care (usual care group, no CPAP), they did not find any significant difference on the recurrence of cardiovascular events. This intriguing finding raises further questions regarding the effect of OSA on cardiovascular events.

中文翻译：

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阻塞性睡眠呼吸暂停和心血管疾病的治疗：我们的目标是错误的吗？

尽管设计稳健且具有良好的统计能力，但与SAVE研究（睡眠呼吸暂停心血管血管终点）相似，ISAACC研究（睡眠呼吸暂停综合征对急性冠状动脉综合征的影响。CPAP的干预作用）未显示阳性。持续气道正压通气（CPAP）治疗阻塞性睡眠呼吸暂停（OSA）的效果，可作为心血管事件的二级预防措施。在本研究和SAVE中观察到的适度但临床上相似的CPAP使用（每晚<3小时）可能至少部分解释了这种影响的消失。但是，当作者将没有OSA的急性冠脉综合征（ACS）的参与者（参考组）与接受常规护理的ASC和OSA的参与者（常规护理组，无CPAP）进行比较时，他们对心血管事件的复发没有发现任何显着差异。这个有趣的发现提出了关于OSA对心血管事件的影响的其他问题。