Migraine is a highly prevalent neurovascular disorder and the second leading cause of disability worldwide. Cortically spreading depolarisations, which underlie migraine auras, connect to the trigeminovascular system that incites migraine headaches. The role of calcitonin gene-related peptide (CGRP) during the aura is still debated, but is certain in the activation of the trigeminovascular complex. 2019 has been an important year in establishing acute and preventive new therapies for migraine.

中文翻译：

---

新兴的头痛疗法：2019年取得进展。

偏头痛是一种高度流行的神经血管疾病，是世界范围内导致残疾的第二大主要原因。偏头痛先兆的皮层去极化作用与引起偏头痛的三叉神经血管系统相连。降钙素基因相关肽（CGRP）在先兆过程中的作用仍在争论中，但在三叉神经血管复合物的激活中是肯定的。2019年是建立偏头痛的急性和预防性新疗法的重要一年。