当前位置: X-MOL 学术Lancet Neurol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Rural origins of warfarin.
The Lancet Neurology ( IF 48.0 ) Pub Date : 2019-12-11 , DOI: 10.1016/s1474-4422(19)30446-6
Taha Nisar , Harry Sutherland-Foggio , Walter Husar

Warfarin might be the most commonly used oral anticoagulant. It was first used as a rodenticide in the 1940s, but found wide acceptance for medical use after the discovery of vitamin K as an antagonist of its action. The characterisation of the anticoagulant properties of warfarin resulted from years of research by Karl Link, at the University of Wisconsin in Madison, USA, and his students Harold Campbell and Mark Stahmann. Their experiments first led to the isolation of dicoumarol and then to the development of warfarin, a more potent anticoagulant than dicoumarol.

中文翻译:

华法林的农村起源。

华法林可能是最常用的口服抗凝剂。它在1940年代首次用作灭鼠剂,但在发现维生素K作为其作用的拮抗剂后,被广泛用于医疗用途。华法林抗凝特性的表征来自美国威斯康星大学的卡尔·林克(Karl Link)和他的学生哈罗德·坎贝尔(Harold Campbell)和马克·斯塔赫曼(Mark Stahmann)多年的研究。他们的实验首先导致了双香豆酚的分离,然后导致了华法林的发展,华法林是一种比双香豆酚更有效的抗凝剂。
更新日期:2019-12-13
down
wechat
bug