OBJECTIVE To elucidate the sleep quality characteristics and factors related to either good or poor sleep quality in acromegaly patients before surgery and to explore sleep quality changes after transsphenoidal surgery and the factors related to these changes. METHODS We prospectively enrolled 39 acromegaly patients and 78 patients with nonfunctioning pituitary adenomas. Scales for anxiety, depression, disease stigma and nasal condition were evaluated. The Pittsburgh Sleep Quality Index (PSQI) questionnaire was administered before surgery as well as one month and three months after surgery. RESULTS A higher percentage of acromegaly patients had poor sleep quality compared to controls (35.9% vs. 5.1%, p < 0.001). In addition, acromegaly patients experienced worse subjective sleep quality, extended sleep latency, increased sleep disturbance and decreased daytime functioning. Higher scores for anxiety, disease stigma and sinonasal outcomes were correlated with worse sleep quality in acromegaly patients. At one month after transsphenoidal surgery, we found worse subjective sleep quality, extended sleep latency, shortened sleep duration, impaired sleep efficiency and increased sleep disturbance in acromegaly patients. At three months postoperatively, most impaired PSQI domains in acromegaly patients recovered to preoperative levels. The use of soluble gauze was related to decreased sleep quality at one month after surgery and severe anxiety and depression were related to improved sleep quality at three months after surgery. CONCLUSIONS Sleep quality was reduced in acromegaly patients. Moreover, sleep quality initially worsened after surgery but later recovered. Emotional problems and the use of soluble gauze were related factors. CLINICAL TRIAL REGISTRATION None.

中文翻译：

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肢端肥大症的睡眠质量以及经蝶窦手术后的睡眠质量变化：一项前瞻性纵向研究。

目的阐明肢端肥大症患者术前的睡眠质量特征及与睡眠质量好坏有关的因素，探讨经蝶窦手术后的睡眠质量变化及与这些变化有关的因素。方法我们前瞻性纳入了39例肢端肥大症患者和78例无功能垂体腺瘤的患者。评估焦虑，抑郁，疾病柱头和鼻腔状况的量表。匹兹堡睡眠质量指数（PSQI）问卷是在手术前以及手术后一个月和三个月进行的。结果与对照组相比，肢端肥大症患者的睡眠质量差（35.9％vs. 5.1％，p <0.001）。此外，肢端肥大症患者的主观睡眠质量较差，睡眠潜伏期延长，睡眠障碍增加，白天功能下降。肢端肥大症患者的焦虑，疾病柱头和鼻窦结局评分较高与睡眠质量较差有关。经蝶骨手术后一个月，我们发现肢端肥大症患者的主观睡眠质量较差，睡眠潜伏期延长，睡眠时间缩短，睡眠效率受损和睡眠障碍增加。术后三个月，肢端肥大症患者的大多数PSQI结构域恢复到术前水平。可溶性纱布的使用与术后1个月睡眠质量下降有关，严重的焦虑和抑郁与术后3个月睡眠质量改善有关。结论肢端肥大症患者的睡眠质量下降。而且，睡眠质量最初在手术后恶化，但后来恢复了。情绪问题和可溶性纱布的使用是相关因素。临床试验注册无。