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Activated Schwann cells and increased inflammatory cytokines IL‐1β, IL‐6, and TNF‐α in patients' sural nerve are lack of tight relationship with specific sensory disturbances in Parkinson's disease
CNS Neuroscience & Therapeutics ( IF 3.394 ) Pub Date : 2019-12-11 , DOI: 10.1111/cns.13282
Hui Zhang; Jing Wu; Fei‐Fei Shen; Yong‐Sheng Yuan; Xiao Li; Pan Ji; Lin Zhu; Li Sun; Jian Ding; Qi Niu; Ke‐Zhong Zhang

Neuroinflammation is one of the most important processes in the pathogenesis of Parkinson's disease (PD). Sensory disturbances are common in patients with PD, but the underlying pathophysiological mechanisms remain unknown. This study aimed to characterize the activation of Schwann cells (SCs) and the increase of expression of inflammatory cytokines IL‐1β, IL‐6, and TNF‐α in the sural nerve of PD, and further explore whether peripheral nerve inflammation is the cause of PD sensory disturbances.
更新日期:2019-12-13

 

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