Background: Findings on the association of sugar sweetened beverages (SSB) and fructose intakes with gout and hyperuricemia have been conflicting.

Objective: We aimed to perform a systematic review and meta-analysis on studies that examined the association of SSB and fructose consumption with gout and hyperuricemia in adults.

Methods: We searched PubMed, Scopus and Google Scholar up to Aug 2017 for all relevant published papers assessing SSB and fructose intakes and risk of gout and hyperuricemia. After excluding non-relevant papers, 10 studies remained in our systematic. Meta-analysis on SSB consumption and risk of gout was done on three effect sizes from cohort studies and five effect sizes from case-control studies. For risk of hyperuricemia, the meta-analysis was done on six effect sizes from cross-sectional studies. All analyses were performed on ORs or RRs.

Results: We found an overall significant positive association between SSB consumption and risk of gout in both cohort (summary effect size: 1.35; 95% CI: 1.18–1.55) and case-control studies (summary effect size: 1.33; 95% CI: 1.06–1.66). Meta-analysis on cross-sectional studies revealed that SSB consumption was associated with 35% greater odds of hyperuricemia (summary effect size: 1.35; 95% CI: 1.19–1.52). No evidence of between-study heterogeneity as well as publication bias was found. Although the studies on fructose intake and risk of gout and hyperuricemia were included in our systematic review, we did not perform met-analysis on these studies due to insufficient number of publications.

Conclusion: We found that SSB consumption was significantly associated with increased risk of gout and hyperuricemia in adult population. Further studies are needed to examine the association between dietary fructose intake and risk of gout and hyepruricemia.

背景：关于含糖饮料（SSB）和果糖摄入与痛风和高尿酸血症之间的关系的研究一直存在矛盾。

目的：我们旨在对研究SSB和果糖摄入与痛风和高尿酸血症的成人之间的关系进行系统的回顾和荟萃分析。

方法：截至2017年8月，我们在PubMed，Scopus和Google Scholar中搜索了所有有关评估SSB和果糖摄入量以及痛风和高尿酸血症风险的相关论文。在排除无关的论文之后，我们的系统中还有10项研究。对SSB摄入量和痛风风险的荟萃分析是根据队列研究中的三种效应大小和病例对照研究中的五种效应大小进行的。对于高尿酸血症的风险，对横断面研究的六个效应量进行了荟萃分析。所有分析均在OR或RR上进行。

结果：我们在队列研究（总影响量：1.35； 95％CI：1.15-1.55）和病例对照研究（总影响量：1.33； 95％CI：两组）中，SSB摄入量与痛风风险之间存在总体显着正相关。 1.06-1.66）。对横断面研究的荟萃分析显示，SSB的摄入与高尿酸血症几率增加35％相关（总效应量：1.35； 95％CI：1.19-1.52）。没有发现研究之间异质性以及发表偏见的证据。尽管我们的系统评价包括了关于果糖摄入以及痛风和高尿酸血症风险的研究，但是由于出版物数量不足，我们没有对这些研究进行met-分析。

结论：我们发现，食用SSB与成人人群痛风和高尿酸血症的风险增加显着相关。需要进一步的研究来检查饮食中果糖摄入与痛风和血尿过多风险之间的关系。