BACKGROUND Breast cancer is the most common cancer among women and it affects quality of life of those women. So far, the two most frequently used tools for assessing health related quality of life in breast cancer patients, EORTC QLQ-C30 and EORTC QLQ-BR23 modules, were not validated in Ethiopia. Hence, the present study aimed to assess the psychometric properties of the tools among Ethiopian breast cancer patients. METHODS Institutional based longitudinal study was conducted from January 1 to May 1, 2017 GC at only nationwide oncology center, Tikur Anbessa Specialized Hospital (TASH), Addis Ababa, Ethiopia. A total of 146 patients who visited the facility during that period, with no missing quality of life data, were selected for analysis. The psychometric properties of the EORTC QLQ-C30 and EORTC QLQ-BR23 were evaluated in terms of reliability, convergent, divergent, construct and clinical validity using SPSS version 22. RESULTS Satisfactory internal consistency reliability (Cronbach's α coefficients > 0.7) was confirmed, except for cognitive function (α = 0.516) of EORTC QLQ-C30 and body image (α = 0.510) of EORTC QLQ-BR23. Multiple-trait scaling analysis demonstrated a good convergent and divergent validity. No scaling errors were observed. Most items in EORTC QLQ-BR23 possessed a weak or no correlation with its own dimension in EORTC QLQ-C30 (r < 0.4) except with some of symptom scales. A statistically significant chemotherapy induced quality of life scores changes (P ≤ 0.05) were observed in all dimensions of both instruments between baseline and the end of first cycle chemotherapy, except for body image (P = 0.985) and sexual enjoyment (P = 0.817) of EORTC QLQ-BR23, indicating clinical validity. CONCLUSION Amharic version of the EORTC QLQ-C30 and EORTC QLQ-BR23 modules are valid and adequately reliable tool and can be used for clinical and epidemiological cancer researches to study the health related quality of life (HRQoL) of women with breast cancer in Ethiopia.

中文翻译：

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用于评估埃塞俄比亚乳腺癌患者健康相关生活质量的EORTC QLQ-C30和QLQ-BR23模块的Amharic版本的可靠性和有效性。

背景技术乳腺癌是女性中最常见的癌症，并且它影响那些女性的生活质量。迄今为止，埃塞俄比亚尚未验证两种最常用的评估乳腺癌患者健康相关生活质量的工具，即EORTC QLQ-C30和EORTC QLQ-BR23模块。因此，本研究旨在评估该工具在埃塞俄比亚乳腺癌患者中的心理计量学特性。方法基于机构的纵向研究于2017年1月1日至5月1日在埃塞俄比亚亚的斯亚贝巴的提库尔·安贝萨专科医院（TASH）的全国肿瘤学中心进行。在此期间，总共146名无视生活质量数据的就诊设施的患者被选择进行分析。评估了EORTC QLQ-C30和EORTC QLQ-BR23的心理性能，结果使用SPSS 22版具有收敛性，差异性，构造性和临床有效性。结果除了EORTC QLQ-C30的认知功能（α= 0.516）和人体图像（α= 0.510）之外，其他方面的内部一致性信度（Cronbach'sα系数> 0.7）也令人满意。的EORTC QLQ-BR23。多特征量表分析显示出良好的收敛性和发散性有效性。没有观察到缩放错误。EORTC QLQ-BR23中的大多数项目与EORTC QLQ-C30中的自身尺寸无关或无相关性（r <0.4），除了某些症状量表。从基线到第一轮化疗结束之间，所有仪器在所有维度上均观察到化学诱导的生活质量得分变化具有统计学意义（P≤0.05），身体图像（P = 0.985）和性愉悦性（P = 0.817）除外。的EORTC QLQ-BR23，表明临床有效性。结论EORTC QLQ-C30和EORTC QLQ-BR23模块的Amharic版本是有效且足够可靠的工具，可用于临床和流行病学癌症研究，以研究埃塞俄比亚乳腺癌妇女的健康相关生活质量（HRQoL）。