The hypoxia-induced resistance to radiotherapy (RT) is a great threat to cancer patients. Therefore, overcoming the hypoxia tumor microenvironment is a vital issue. Herein, spindle-shaped CuS@CeO2 core-shell nanoparticles combining self-supplied oxygen, photothermal ability, and RT sensitive to cancer therapy are introduced. The spindle shape of CuS@CeO2 core-shell nanoparticles can potentiate their tumor penetration and subsequent internalization by cancer cells. The presence of CeO2 , functioning as a nanoenzyme, catalyzes the endogenous H2 O2 in tumor tissue into O2 , which remodels the hypoxic microenvironment into one susceptible to RT. CuS nanoparticles encapsulated in CeO2 undergo a steady release and deep tumor penetration, allowing the regression of lesions less affected by RT. Furthermore, in vitro and in vivo studies reveal that the design not only mitigates the dosage of RT, but more importantly allows the entire tumor to be treated without relapses.

中文翻译：

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用于深层缺氧肿瘤治疗的氧气自发多阶段输送系统。

低氧诱导的对放射治疗的抵抗力（RT）对癌症患者构成了巨大威胁。因此，克服缺氧肿瘤的微环境是至关重要的问题。在这里，介绍了主轴形状的CuS @ CeO2核壳纳米粒子，结合了自我提供的氧气，光热能力和对癌症治疗敏感的RT。CuS @ CeO2核壳纳米粒子的纺锤形可以增强其肿瘤渗透能力，并随后被癌细胞内化。CeO2作为一种纳米酶的存在，可将肿瘤组织中的内源性H2 O2催化转化为O2，从而将低氧微环境重塑为对RT敏感的环境。包裹在CeO2中的CuS纳米粒子经历了稳定释放和深层肿瘤渗透，使病变受RT影响较小的消退。此外，