The fetal environment has been increasingly implicated in later psychological health, but the role of lipids is unknown. Drawing on the ethnically diverse Born in Bradford (BiB) birth cohort, the current study related levels of high-density lipoprotein (HDL), very-low-density lipoprotein (VLDL), and triglycerides in umbilical cord blood to 1,369 children’s teacher-rated psychosocial competence approximately 5 years later. Results of ordinal logistic regressions indicated that low levels of HDL, high levels of VLDL, and high levels of triglycerides predicted greater likelihood of being rated as less competent in domains of emotion regulation, self-awareness, and interpersonal functioning. Furthermore, these results generalized across ethnic background and children’s sex and were not accounted for by variables reflecting mothers’ psychological or physical health, children’s physical health, or children’s special education status. Together, these results identify fetal exposure to anomalous lipid levels as a possible contributor to subsequent psychological health and social functioning.

中文翻译：

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出生时的血脂状况可预测 5 年后教师评定的儿童情绪和社会发展

胎儿环境越来越多地与后期的心理健康有关，但脂质的作用尚不清楚。借鉴布拉德福德出生 (BiB) 出生队列的种族多样性，目前的研究将脐带血中高密度脂蛋白 (HDL)、极低密度脂蛋白 (VLDL) 和甘油三酯的水平与 1,369 名教师评定的儿童相关大约 5 年后的社会心理能力。有序逻辑回归的结果表明，低水平的 HDL、高水平的 VLDL 和高水平的甘油三酯预示着在情绪调节、自我意识和人际关系功能领域被评为能力较差的可能性更大。此外，这些结果概括了种族背景和儿童的性别，并没有被反映母亲心理或身体健康、儿童身体健康或儿童特殊教育状况的变量解释。总之，这些结果将胎儿暴露于异常脂质水平确定为随后的心理健康和社会功能的可能因素。