Quinazoline-Containing Indole Alkaloids from the Marine-Derived Fungus Aspergillus sp. HNMF114.,Journal of Natural Products

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Quinazoline-Containing Indole Alkaloids from the Marine-Derived Fungus Aspergillus sp. HNMF114.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2019-12-11 , DOI: 10.1021/acs.jnatprod.9b00845
Fan-Dong Kong ₁ , Sheng-Liang Zhang ₂ , Shuang-Qing Zhou ₂ , Qing-Yun Ma ₁ , Qing-Yi Xie ₁ , Jin-Ping Chen ₁ , Jiu-Hui Li ₁ , Li-Man Zhou ₁ , Jing-Zhe Yuan ₁ , Zhong Hu ₃ , Hao-Fu Dai ₁ , Xiao-Long Huang ₂ , You-Xing Zhao ₁

Affiliation

Seven new quinazoline-containing indole alkaloids (1-7) named aspertoryadins A-G, along with nine known ones (8-16), were isolated from the marine-derived fungus Aspergillus sp. HNMF114 from the bivalve mollusk Sanguinolaria chinensis. The structures of the new compounds were elucidated from spectroscopic data, X-ray diffraction analysis, ECD spectra analysis, and ECD calculations. Compound 1 bears an aminosulfonyl group in the structure, which is rarely encountered in natural products. Compounds 6, 7, and 13 exhibited quorum sensing inhibitory activity against Chromobacterium violaceum CV026 with MIC values of 32, 32, and 16 μg/well, respectively.

中文翻译：

海洋衍生真菌曲霉菌中含喹唑啉的吲哚生物碱。HNMF114。

从海洋真菌Aspergillus sp。中分离出了七个新的含喹唑啉的吲哚生物碱（1-7），称为aspertoryadins AG，还有九个已知的吲哚生物碱（8-16）。来自双壳软体动物Sanguinolaria chinensis的HNMF114。从光谱数据，X射线衍射分析，ECD光谱分析和ECD计算中阐明了新化合物的结构。化合物1在结构中带有氨基磺酰基，这在天然产物中很少见。化合物6、7和13表现出对紫罗兰色杆菌CV026的群体感应抑制活性，MIC值分别为32、32和16μg/孔。

更新日期：2019-12-11

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