Nanostructured biomaterials have great potential in the field of biomedical engineering. Efforts for treatment of cardiovascular diseases focused on introducing vascular substitutes that are nonthrombogenic and have long‐term patency, but still there is not any perfect replacement for clinical use. In this study, nanostructure tubes of a commonly known biocompatible polymer, polyethylene terephthalate (PET), were prepared via electrospinning process using small diameter mandrel as a collector with two different speeds. The nanofibers (NFs) morphologies' physical and mechanical properties were investigated according to scanning electron microscope (SEM), water contact angle (WCA), porosity measurement, differential scanning calorimetry (DSC), and tensile test. Finer NFs, more percentage of crystallinity, and superior mechanical properties were observed for samples prepared by higher speed mandrel. Since both samples stimulated platelet adhesion and activation, further surface modification with sodium nitrate as nitric oxide (NO) donor was done using two different approaches: dip‐coating and electrospraying. The modified NFs were evaluated via SEM, WCA, tensile test, platelets, and cell adhesion. The results showed more hydrophilicity, reduction in platelet adhesion, and improved blood compatibility for eNO‐HS (electrosprayed NO for higher collector speed) compared with other samples implying the promising potential of this fabrication and modification technique for improving PET‐based cardiovascular substitutes.

中文翻译：

---

用于生物医学应用的电纺聚对苯二甲酸乙二酯（PET）纳米纤维导管

纳米结构生物材料在生物医学工程领域具有巨大潜力。心血管疾病的治疗重点是引入非血栓形成且具有长期开放性的血管替代物，但临床上尚无完美替代物。在这项研究中，使用小直径心轴作为收集器以两种不同速度通过静电纺丝工艺制备了一种众所周知的生物相容性聚合物聚对苯二甲酸乙二醇酯（PET）的纳米结构管。通过扫描电子显微镜（SEM），水接触角（WCA），孔隙率测量，差示扫描量热法（DSC）和拉伸试验研究了纳米纤维（NFs）形态的物理和机械性能。NF越细，结晶度越高，通过高速芯棒制备的样品观察到了优异的机械性能。由于两个样品都刺激血小板粘附和活化，因此使用两种不同的方法使用硝酸钠作为一氧化氮（NO）供体进行了进一步的表面修饰：浸涂和电喷涂。通过SEM，WCA，拉伸试验，血小板和细胞粘附力评估了修饰的NF。结果显示，与其他样品相比，eNO-HS（电喷雾NO可提高收集器速度）具有更大的亲水性，血小板粘附性降低和血液相容性提高，这表明这种制备和修饰技术有望改善基于PET的心血管替代品。使用硝酸钠作为一氧化氮（NO）供体进行了进一步的表面改性，这是通过两种不同的方法完成的：浸涂和电喷涂。通过SEM，WCA，拉伸试验，血小板和细胞粘附力评估了修饰的NF。结果显示，与其他样品相比，eNO-HS（电喷雾NO可提高收集器速度）具有更大的亲水性，血小板粘附性降低和血液相容性改善，这表明这种制备和修饰技术有望改善基于PET的心血管替代品。使用硝酸钠作为一氧化氮（NO）供体进行了进一步的表面改性，这是通过两种不同的方法完成的：浸涂和电喷涂。通过SEM，WCA，拉伸试验，血小板和细胞粘附力评估了修饰的NF。结果显示，与其他样品相比，eNO-HS（电喷雾NO可提高收集器速度）具有更大的亲水性，血小板粘附性降低和血液相容性提高，这表明这种制备和修饰技术有望改善基于PET的心血管替代品。