Determination of the Binding Situation of Pyridine in Xylan Sulfates by Means of Detailed NMR Studies,Macromolecular Chemistry and Physics

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Determination of the Binding Situation of Pyridine in Xylan Sulfates by Means of Detailed NMR Studies
Macromolecular Chemistry and Physics ( IF 2.5 ) Pub Date : 2019-10-10 , DOI: 10.1002/macp.201900327
Lars Gabriel ₁ , Wolfgang Günther ₁ , Friederike Pielenz ₁ , Thomas Heinze ₁

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Xylan sulfate is an important drug to treat interstitial cystitis. Production of the drug by sulfation of the polysaccharide with a sulfating agent like chlorosulfuric acid and pyridine–SO₃ complex in pyridine may lead to products containing pyridine‐based impurities. Xylan sulfate containing nitrogen is investigated by different NMR measurements in order to clarify the binding situation of pyridine. The detailed NMR studies allow the conclusion that the pyridine‐based impurities are covalently bonded to the reducing end group. Furthermore, the NMR spectroscopic investigation indicates that the side reactions occur at shorter polymer chains only.

中文翻译：

通过详细的NMR研究确定硫酸木聚糖中吡啶的结合情况

硫酸木聚糖是治疗间质性膀胱炎的重要药物。通过在吡啶中使用诸如硫酸硫酸和吡啶-SO ₃络合物之类的硫酸化剂将多糖硫酸化来生产药物，可能会导致产品中含有吡啶基杂质。通过不同的NMR测量研究了含氮的木聚糖硫酸盐，以阐明吡啶的结合情况。详细的NMR研究得出这样的结论：吡啶基杂质与还原端基共价键合。此外，NMR光谱研究表明副反应仅在较短的聚合物链上发生。

更新日期：2019-10-10

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