Previous reports of some studies have described that nitrogen (N)‐doped titanium dioxide (TiO₂) exhibits photocatalytic antibacterial activity under visible light irradiation and that reactive oxygen species (ROS) is involved in its activity. For prevention and treatment of peri‐implantitis, an inflammatory lesion caused by the bacterial infection of plaque adhering to the circumference of an implant, we considered that applying N‐doped TiO₂ to dental implant surfaces can be effective. For this study, we aimed at evaluating visible light‐induced antibacterial activity of titanium (Ti) treated with NaOH and hot water, and subsequently heated in an ammonia (NH₃) gas atmosphere at 500°C for 3 hr to quantify the generated amount of ROS available for antibacterial activity. N‐doped anatase‐type titania (TiO₂‐xNx) is formed on the Ti substrate surface. Under visible light, markedly more hydroxyl radicals were generated with a nitrogen‐doped titanium dioxide plate than with a pure titanium plate. Hydrogen peroxide exhibited the same tendency. Furthermore, it showed visible light‐induced antibacterial effects over Escherichia coli. Results demonstrate that N‐doped TiO₂ can be useful as a dental implant surface with low risk of postoperative infection when using visible light irradiation.

中文翻译：

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N掺杂二氧化钛的可见光诱导光催化和抗菌活性。

之前的一些研究报告描述了氮（N）掺杂的二氧化钛（TiO ₂）在可见光照射下表现出光催化抗菌活性，并且活性氧（ROS）参与了其活性。为了预防和治疗种植体周围炎，这是一种由附着在种植体周围的菌斑细菌感染引起的炎症性病变，我们认为将 N 掺杂的 TiO ₂应用于种植体表面是有效的。在本研究中，我们旨在评估用 NaOH 和热水处理的钛 (Ti) 的可见光诱导抗菌活性，然后在氨 (NH ₃) 在 500°C 的气体气氛中保持 3 小时，以量化可用于抗菌活性的 ROS 的生成量。N掺杂锐钛矿型二氧化钛（TiO ₂ -xNx）形成在Ti衬底表面。在可见光下，掺氮二氧化钛板产生的羟基自由基明显多于纯钛板。过氧化氢表现出同样的趋势。此外，它对大肠杆菌显示出可见光诱导的抗菌作用。结果表明，当使用可见光照射时，N 掺杂的 TiO ₂可用作牙科植入物表面，术后感染风险低。