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Introduction of a novel guided bone regeneration memory shape based device.
Journal of Biomedical Materials Research Part B: Applied Biomaterials ( IF 3.2 ) Pub Date : 2019-05-08 , DOI: 10.1002/jbm.b.34402
Osama Zakaria 1 , Marwa Madi 2 , Shohei Kasugai 3
Affiliation  

Bone regeneration by periosteal distraction has been reported in numerous animal studies; however, the main disadvantages of this technique are poor bone quality and soft tissue invasion in the distracted space. The purpose of this study was to evaluate a novel shape memory‐based device to promote bone regeneration in a large, secluded growth space in a rabbit model. Twenty rabbits were divided into two groups. In the first group (n = 10), a device composed of silicone sheets and nitinol strips was inserted subperiosteally in the calvarial area. In the second group (n = 10), only silicone sheets were inserted in the calvarial area. Each group was further divided in half: five animals were sacrificed at 8 weeks postoperatively, and the other five were sacrificed at 16 weeks postoperatively. In the study group, the new device vertically expanded the overlying soft tissue 4 mm above the original bone and created a secluded space; the newly generated bone maximum height median ranged between 2.7 mm in 8 weeks group and 2.6 mm in 16 weeks group. In the control group, a very thin rim of bone was generated below the flat silicone sheets on top of the original bone. Maximum bone heights median ranged from 0.37 mm in 8 weeks group to 0.32 mm in 16 weeks group. The device was proven to be effective at vertically augmenting bone by applying the guided bone regeneration and soft tissue expansion procedures simultaneously. This device may pave the way for a new generation of smart guided bone regeneration membranes that can remember the original dimensions of resorbed bone areas.

中文翻译:

介绍一种新型的基于引导骨再生记忆形状的装置。

在许多动物研究中已经报道了通过骨膜牵引进行骨再生。然而,这种技术的主要缺点是骨质量差和分散空间中的软组织侵入。本研究的目的是评估一种新型的基于形状记忆的装置,以促进兔子模型中大而隐蔽的生长空间中的骨再生。二十只兔子被分成两组。在第一组(n = 10)中,由硅胶片和镍钛诺条组成的装置被插入到颅骨区域的骨膜下。在第二组(n= 10),仅在颅骨区域插入硅胶片。每组进一步分成两半:5只动物在术后8周处死,另外5只在术后16周处处死。在研究组中,新装置将覆盖的软组织垂直扩张到原始骨骼上方 4 毫米处,并创造了一个僻静的空间;新生成的骨最大高度中位数介于 8 周组的 2.7 毫米和 16 周组的 2.6 毫米之间。在对照组中,在原始骨骼顶部的平坦硅胶片下方生成了非常薄的骨骼边缘。最大骨高度中位数从 8 周组的 0.37 毫米到 16 周组的 0.32 毫米不等。通过同时应用引导骨再生和软组织扩张程序,该设备被证明在垂直增强骨骼方面是有效的。
更新日期:2019-05-08
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