Several nerve conduits have been investigated for their potential as alternative sources of autografts for bridging neural gaps. However, autologous nerve transplants remain the most effective for nerve repair. We examined clinically approved nerve conduits containing collagen and polyglycolic acid (PGA‐c) combined with collagen‐binding basic fibroblast growth factor (bFGF) containing a polycystic kidney disease (PKD) domain and collagen binding domain (CBD) (bFGF‐PKD‐CBD) in a rat 15‐mm sciatic nerve critical‐size defect model. The treatment groups were: PGA‐c immersed in phosphate‐buffered saline (PBS) (PGA‐c/PBS group), bFGF (PGA‐c/bFGF group), or bFGF‐PKD‐CBD (PGA‐c/bFGF‐PKD‐CBD group), and no treatment (Defect group). Gait and histological analyses were performed. Four weeks after treatment, the recovery rate of the paw print area was significantly greater in the PGA‐c/bFGFPKD‐CBD group than the PGA‐c/PBS and PGA‐c/bFGF groups. Mean intensity of paw prints was significantly greater in the PGA‐c/bFGF‐PKD‐CBD group than the PGA‐c/PBS and Defect groups. Swing time was significantly greater in the PGA‐c/PBS, PGA‐c/bFGF, and PGA‐c/bFGF‐PKD‐CBD groups than the Defect group. At 8 weeks, all three parameters were significantly greater in the PGA‐c/PBS, PGA‐c/bFGF, and PGA‐c/bFGF‐PKD‐CBD groups than the Defect group. Regenerated myelinated fibers were observed in 7/8 (87.5%) rats in the PGA‐c/bFGF‐PKD‐CBD group after 8 weeks, and in 1/8 (12.5%) and 3/8 (37.5%) rats in the PGA‐c/PBS and PGA‐c/bFGF groups, respectively. PGA‐c/bFGF‐PKD‐CBD composites may be promising biomaterials for promoting functional recovery of long‐distance peripheral nerve defects in clinical practice.

中文翻译：

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聚乙醇酸-胶原管结合胶原结合碱性成纤维细胞生长因子加速大鼠坐骨神经临界尺寸缺损模型的步态恢复。

已经研究了几种神经导管作为桥接神经间隙的自体移植物的替代来源的潜力。然而，自体神经移植仍然是神经修复最有效的方法。我们检查了临床批准的含有胶原蛋白和聚乙醇酸 (PGA-c) 的神经导管，以及含有多囊肾病 (PKD) 结构域和胶原蛋白结合结构域 (CBD) (bFGF-PKD-CBD) 的胶原结合碱性成纤维细胞生长因子 (bFGF) ) 在大鼠 15 毫米坐骨神经临界尺寸缺损模型中。治疗组为：PGA-c 浸入磷酸盐缓冲盐水 (PBS)（PGA-c/PBS 组）、bFGF（PGA-c/bFGF 组）或 bFGF-PKD-CBD（PGA-c/bFGF-PKD ‐CBD 组）和无治疗（缺陷组）。进行步态和组织学分析。治疗后四个星期，PGA-c/bFGFPKD-CBD 组爪印区域的恢复率显着高于 PGA-c/PBS 和 PGA-c/bFGF 组。PGA-c/bFGF-PKD-CBD 组的爪印平均强度明显高于 PGA-c/PBS 和缺陷组。PGA-c/PBS、PGA-c/bFGF 和 PGA-c/bFGF-PKD-CBD 组的摆动时间明显长于缺陷组。在第 8 周时，PGA-c/PBS、PGA-c/bFGF 和 PGA-c/bFGF-PKD-CBD 组的所有三个参数均显着高于缺陷组。8 周后，在 PGA-c/bFGF-PKD-CBD 组的 7/8 (87.5%) 只大鼠和 1/8 (12.5%) 和 3/8 (37.5%) 只大鼠中观察到再生有髓纤维。分别为 PGA-c/PBS 和 PGA-c/bFGF 组。