Combinatorial Development and in‐vitro Characterization of the Quaternary Zr‐Ti‐X‐Y (X‐Y=Cu‐Ag/Co‐Ni) Metallic Glass for Prospective Bio‐Implants,Advanced Engineering Materials

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Combinatorial Development and in‐vitro Characterization of the Quaternary Zr‐Ti‐X‐Y (X‐Y=Cu‐Ag/Co‐Ni) Metallic Glass for Prospective Bio‐Implants
Advanced Engineering Materials ( IF 3.4 ) Pub Date : 2019-10-18 , DOI: 10.1002/adem.201900726
Akib Jabed ₁ , Zia Ur Rahman _{1,

2} , Muhammad Mudasser Khan ₁ , Waseem Haider _{1,

2} , Ishraq Shabib _{1,

2}

Affiliation

The prospect of Zr-based metallic glasses (MGs) in achieving a combination of properties, such as excellent electrochemical properties and extended biocompatibility, has been studied in this work. The combinatorial method (magnetron co-sputtering) has been adopted to fabricate two novel quaternary MG systems (Zr50Ti32Cu13Ag5 and Zr40Ti37Co12Ni11) with optimized compositions. The structural analysis has been performed by the grazing incidence x-ray diffraction and high-resolution transmission electron microscopy to affirm the disordered structure of the MG systems. The electrochemical analysis demonstrates lower corrosion(0.10 and 0.04 μA cm ), and passive (2.93 and 1.88 μA cm ) current densities of the MGs. In addition, the MGs are found to have higher charge transfer resistance (4.70 and 7.86MΩ cm) compared to the 316L stainless steel (SS) (0.15 MΩ cm) and cp-Ti (0.53MΩ cm). The electrochemical features are indicative towards higher corrosion-resistance capabilities of Zr50Ti32Cu13Ag5 and Zr40Ti37Co12Ni11 MGs to prevent adverse biological reactions. Additionally, the cell proliferation analysis manifests higher cell proliferation on the Zr50Ti32Cu13Ag5 and Zr40Ti37Co12Ni11 MGs for the MC3T3-E1 preosteoblast cells. Besides, the MTS assay analysis strengthens the prediction of cytocompatibility of the MGs. The integration of such unique properties makes these MG systems ideal candidates for biomedical implants.

中文翻译：

用于前瞻性生物植入物的四元 Zr-Ti-X-Y (X-Y=Cu-Ag/Co-Ni) 金属玻璃的组合开发和体外表征

这项工作已经研究了 Zr 基金属玻璃 (MGs) 在实现性能组合方面的前景，例如优异的电化学性能和扩展的生物相容性。采用组合方法（磁控管共溅射）制造了两种具有优化成分的新型四元MG系统（Zr50Ti32Cu13Ag5和Zr40Ti37Co12Ni11）。通过掠入射 x 射线衍射和高分辨率透射电子显微镜进行结构分析, 以确认 MG 系统的无序结构。电化学分析表明 MG 具有较低的腐蚀（0.10 和 0.04 μA cm ）和钝化（2.93 和 1.88 μA cm ）电流密度。此外，发现 MG 与 316L 不锈钢 (SS) 相比具有更高的电荷转移电阻（4.70 和 7.86MΩ cm）（0. 15 MΩ cm) 和 cp-Ti (0.53MΩ cm)。电化学特性表明 Zr50Ti32Cu13Ag5 和 Zr40Ti37Co12Ni11 MGs 具有更高的耐腐蚀性能，以防止不良生物反应。此外，细胞增殖分析表明，对于 MC3T3-E1 前成骨细胞，Zr50Ti32Cu13Ag5 和 Zr40Ti37Co12Ni11 MG 具有更高的细胞增殖。此外，MTS 检测分析加强了对 MG 细胞相容性的预测。这种独特特性的整合使这些 MG 系统成为生物医学植入物的理想候选者。细胞增殖分析表明，对于 MC3T3-E1 前成骨细胞，Zr50Ti32Cu13Ag5 和 Zr40Ti37Co12Ni11 MG 具有更高的细胞增殖。此外，MTS 检测分析加强了对 MG 细胞相容性的预测。这种独特特性的整合使这些 MG 系统成为生物医学植入物的理想候选者。细胞增殖分析表明，对于 MC3T3-E1 前成骨细胞，Zr50Ti32Cu13Ag5 和 Zr40Ti37Co12Ni11 MG 具有更高的细胞增殖。此外，MTS 检测分析加强了对 MG 细胞相容性的预测。这种独特特性的整合使这些 MG 系统成为生物医学植入物的理想候选者。

更新日期：2019-10-18

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