Carbonate apatite (CO₃Ap) granules are known to show good osteoconductivity and replaced to new bone. On the other hand, it is well known that a porous structure allows bone tissue to penetrate its pores, and the optimal pore size for bone ingrowth is dependent on the composition and structure of the scaffold material. Therefore, the aim of this study was to fabricate various porous CO₃Ap granules through a two‐step dissolution–precipitation reaction using CaSO₄ as a precursor and 30‐, 50‐, 120‐, and 205‐μm diameter microfibers as porogen and to find the optimal pore size of CO₃Ap. Porous CO₃Ap granules were successfully fabricated with pore size 8.2–18.7% smaller than the size of the original fiber porogen. Two weeks after the reconstruction of rabbit calvarial bone defects using porous CO₃Ap granules, the largest amount of mature bone was seen to be formed inside the pores of CO₃Ap (120) [porous CO₃Ap granules made using 120‐μm microfiber] followed by CO₃Ap (50) and CO₃Ap (30). At 4 and 8 weeks, no statistically significant difference was observed based on the pore size, even though largest amount of mature bone was formed in case of CO₃Ap (120). It is concluded, therefore, that the optimal pore size of the CO₃Ap is that of CO₃Ap (120), which is 85 μm.

中文翻译：

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使用微纤维制备多孔碳酸盐磷灰石颗粒及其在兔颅骨缺损中的组织学评价。

已知碳酸盐磷灰石 (CO ₃ Ap) 颗粒显示出良好的骨传导性并替换为新骨。另一方面，众所周知，多孔结构允许骨组织穿透其孔隙，骨向内生长的最佳孔径取决于支架材料的组成和结构。因此，本研究的目的是通过使用 CaSO ₄作为前体和 30-、50-、120- 和 205-μm 直径的微纤维作为致孔剂，通过两步溶解-沉淀反应制备各种多孔 CO ₃ Ap 颗粒。寻找最佳的 CO ₃ Ap孔径。多孔 CO ₃Ap 颗粒成功制造，孔径比原始纤维致孔剂的尺寸小 8.2-18.7%。使用多孔 CO ₃ Ap 颗粒重建兔颅骨缺损两周后，观察到最大量的成熟骨形成在 CO ₃ Ap (120) [使用 120-μm 超细纤维制成的多孔 CO ₃ Ap 颗粒的孔内] 然后是CO ₃ Ap (50) 和CO ₃ Ap (30)。在第 4 周和第 8 周，尽管在 CO ₃ Ap 的情况下形成了最大量的成熟骨，但基于孔径没有观察到统计学上的显着差异(120)。因此，可以得出结论，CO ₃ Ap的最佳孔径是 CO ₃Ap (120)，为 85 μm。