Modular Design of Stimuli‐Responsive Supramolecular Nanocarriers Based on Pro‐Guest Strategy,ChemNanoMat

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Modular Design of Stimuli‐Responsive Supramolecular Nanocarriers Based on Pro‐Guest Strategy
ChemNanoMat ( IF 2.6 ) Pub Date : 2019-11-22 , DOI: 10.1002/cnma.201900577
Weipeng Mao ₁ , Xuan Yang ₁ , Da Ma ₁

Affiliation

High affinity host‐guest interactions were used to assemble supramolecular nanocarriers, and controlled release cargo based on a “pro‐guest” strategy. Supramolecular nanocarriers were prepared by modular design, which were responsive to photo‐irradiation or reducing agents. Model cargo nile red was stably encapsulated by nanocarriers in water, and released when photo‐irradiation or reducing agent was applied. Cargo release rate was tunable by using different pro‐guests for photo‐responsive nanocarriers. A mechanistic study was carried out to confirm a cascade process of stimuli‐responsive pro‐guest degradation and competitive displacement. Supramolecular nanocarriers were able to deliver model cargo to the cell cytoplasm.

中文翻译：

基于Pro-Guest策略的刺激响应性超分子纳米载体的模块化设计

高亲和力的主客体相互作用被用于组装超分子纳米载体，并基于“客体”策略控制释放货物。超分子纳米载体是通过模块化设计制备的，它们对光辐射或还原剂有反应。尼罗河红模型货物被纳米载体稳定地包裹在水中，并在施加光辐照或还原剂后释放。通过对光响应性纳米载体使用不同的来宾，可以调节货物的释放速度。进行了一项机械研究，以确认刺激响应的客体退化和竞争性位移的级联过程。超分子纳米载体能够将模型货物递送至细胞质。

更新日期：2019-11-22

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