Unsaturation‐Dependent Nanostructures Self‐Assembled from Oligopeptide Amphiphiles Capable of Generating Singlet Oxygen,ChemNanoMat

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Unsaturation‐Dependent Nanostructures Self‐Assembled from Oligopeptide Amphiphiles Capable of Generating Singlet Oxygen
ChemNanoMat ( IF 2.6 ) Pub Date : 2019-11-19 , DOI: 10.1002/cnma.201900549
Jia‐Ru Feng ₁ , Si‐Yong Qin ₁ , Lei Rong ₂ , Yin‐Jia Cheng ₁ , Yi‐Han Ma ₁ , Ai‐Qing Zhang ₁

Affiliation

We report here on three oligopeptide amphiphiles (OPA1‐3) with different unsaturated double bonds, which self‐assemble into shape‐specific nanostructures. It was found that OPA1 with saturated hydrophobic tail self‐assembled into conventional cylindrical nanofibers, while the unsaturated OPA2‐3 molecules self‐organized into helical nanoarchitectures. Due to the different double bond numbers in hydrophobic tails of OPA2‐3, the helical pitch and width of their self‐assemblies varied. Specially, linoleic acid‐bearing OPA3 could be oxidized by lipoxidase to create hydroperoxide‐containing OPA4, which further generated singlet oxygen (¹O₂) in the presence of catalytic iron (II) ion. The established system may provide a self‐deliverable nanoplatform for ¹O₂‐mediated cancer treatment.

中文翻译：

从寡肽两亲物自组装的不饱和依赖性纳米结构能够产生单线态氧。

我们在此报告了三个具有不同不饱和双键的寡肽两亲物（OPA1-3），它们可自组装成特定形状的纳米结构。发现具有饱和疏水尾巴的OPA1自组装为常规的圆柱形纳米纤维，而不饱和OPA2-3-3分子自组织为螺旋纳米结构。由于OPA2-3的疏水性尾部中的双键数不同，因此它们的自组装螺旋节距和宽度各不相同。特别是，亚油酸中的OPA3可以被脂氧化酶氧化，生成含氢过氧化物的OPA4，在催化性铁离子（II）的存在下，它可以进一步产生单线态氧（¹ O ₂）。已建立的系统可能会为¹ O提供可自我交付的纳米平台₂介导的癌症治疗。

更新日期：2019-11-19

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