DOTA-Branched Organic Frameworks as Giant and Potent Metal Chelators,Journal of the American Chemical Society

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DOTA-Branched Organic Frameworks as Giant and Potent Metal Chelators
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2019-12-11 , DOI: 10.1021/jacs.9b09269
Chengjie Sun ₁ , Hongyu Lin ₁ , Xuanqing Gong ₁ , Zhaoxuan Yang ₁ , Yan Mo ₁ , Xiaoyuan Chen ₂ , Jinhao Gao ₁

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Multinuclear complexes as metallo-agents for clinical use have caught extensive attention. In this paper, using DOTA as both a functioning unit and a constructing junction, we build a series of DOTA-branched organic frameworks (DBOF) with multiple chelating holes by organizing DOTA layer by layer. These giant chelators are well characterized, which re-veals their nano-sized and soft structures. Further experiments demonstrate that they could efficiently hold abundant metal ions with much higher kinetic stabilities than the conventional small DOTA chelator. Their corresponding polynu-clear complexes containing Gd3+, Tb3+, or both show superior imaging properties, excellent feasibility for peripheral modi-fication, and unusual kinetic stability. This work can be easily extended to the fabrication of diverse homo-multinuclear complexes and core/shell hetero-multinuclear complexes with multifunctional properties. We expect that this new type of giant molecules and the ligand-branching strategy would open up a new avenue for the design and construction of next-generation polymetallic agents with high performance and stabilities for biomedical applications.

中文翻译：

DOTA 分支有机框架作为巨大而有效的金属螯合剂

多核配合物作为临床使用的金属制剂引起了广泛关注。在本文中，我们将 DOTA 作为功能单元和构建连接点，通过逐层组织 DOTA，构建了一系列具有多个螯合孔的 DOTA 分支有机框架（DBOF）。这些巨大的螯合剂得到了很好的表征，揭示了它们的纳米尺寸和柔软的结构。进一步的实验表明，与传统的小型 DOTA 螯合剂相比，它们可以有效地保持丰富的金属离子，并具有更高的动力学稳定性。它们相应的含有 Gd3+、Tb3+ 或两者的多核复合物显示出优异的成像特性、出色的周边修饰可行性和异常的动力学稳定性。这项工作可以很容易地扩展到具有多功能特性的各种同多核配合物和核/壳异质多核配合物的制造。我们期望这种新型巨分子和配体分支策略将为设计和构建用于生物医学应用的高性能和稳定性的下一代多金属试剂开辟一条新途径。

更新日期：2019-12-11

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