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Terphenyl derivatives and terpenoids from a wheat-born mold Aspergillus candidus.
The Journal of Antibiotics ( IF 2.668 ) Pub Date : 2019-12-11 , DOI: 10.1038/s41429-019-0266-9
JunJie Han,FangMing Lu,Li Bao,HanYing Wang,BaoSong Chen,ErWei Li,ZhengDi Wang,LiPing Xie,ChangBin Guo,YanFen Xue,YanHe Ma,HongWei Liu

A new p-terphenyl derivative aspergicandidusin A (1), a new cleistanthane diterpenoid 6-deoxyaspergiloid C (13), and 12 known compounds (2-12, and 14) were isolated from the mold Aspergillus candidus. The structures of the new compounds were elucidated by spectral analysis of NMR and MS data. The absolute configuration of C-1 in 13 was determined via the circular dichroism data of the [Rh2(OCOCF3)4] complex. Compounds 2-8 and 11 showed moderate inhibitory activity against K562 cell lines with the IC50 value in the range from 17.9 to 46.3 μM. Compound 13 exhibited moderate cytotoxicity against HepG2 cells with the IC50 value of 47.7 μM. Compounds 11 and 12 exhibited moderate activity against the growth of S. aureus with MIC value of 6.25 μM, respectively.
更新日期:2019-12-11

 

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