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Terphenyl derivatives and terpenoids from a wheat-born mold Aspergillus candidus.
The Journal of Antibiotics ( IF 3.3 ) Pub Date : 2019-12-11 , DOI: 10.1038/s41429-019-0266-9
JunJie Han 1, 2, 3 , FangMing Lu 4 , Li Bao 1, 3 , HanYing Wang 4 , BaoSong Chen 1, 3 , ErWei Li 1, 3 , ZhengDi Wang 5 , LiPing Xie 5 , ChangBin Guo 5 , YanFen Xue 2 , YanHe Ma 2 , HongWei Liu 1, 3
Affiliation  

A new p-terphenyl derivative aspergicandidusin A (1), a new cleistanthane diterpenoid 6-deoxyaspergiloid C (13), and 12 known compounds (2-12, and 14) were isolated from the mold Aspergillus candidus. The structures of the new compounds were elucidated by spectral analysis of NMR and MS data. The absolute configuration of C-1 in 13 was determined via the circular dichroism data of the [Rh2(OCOCF3)4] complex. Compounds 2-8 and 11 showed moderate inhibitory activity against K562 cell lines with the IC50 value in the range from 17.9 to 46.3 μM. Compound 13 exhibited moderate cytotoxicity against HepG2 cells with the IC50 value of 47.7 μM. Compounds 11 and 12 exhibited moderate activity against the growth of S. aureus with MIC value of 6.25 μM, respectively.

中文翻译:

小麦出生的霉菌曲霉曲霉的三联苯衍生物和萜类化合物。

从霉菌曲霉中分离出一种新的对-三苯衍生物曲霉黄酮A(1),一种新的Leistanthane二萜类6-脱氧天冬氨酸C(13)和12种已知化合物(2-12和14)。通过NMR和MS数据的光谱分析阐明了新化合物的结构。通过[Rh2(OCOCF3)4]络合物的圆二色性数据确定13中C-1的绝对构型。化合物2-8和11对K562细胞系表现出中等抑制活性,IC50值在17.9至46.3μM的范围内。化合物13对HepG2细胞表现出中等的细胞毒性,IC50值为47.7μM。化合物11和12分别显示出针对金黄色葡萄球菌生长的中等活性,MIC值为6.25μM。
更新日期:2019-12-11
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