Dual meshes are often preferred in the treatment of umbilical and incisional hernias where the abdominal wall defect is large. These meshes are generally composed of either two nonabsorbable layers or a nonabsorbable layer combined with an absorbable one that degrades within the body upon healing of the defect. The most crucial point in the design of a dual mesh is to produce the respective layers based on the structure and requirements of the recipient site. We herein developed a dual mesh that consists of two layers: a nanofibrous layer made of poly (glycerol sebacate)/poly (caprolactone) (PGS/PCL) to support the healing of the abdominal wall defect and a nondegradable, nonadhesive smooth layer made of polycarbonateurethane (PU) with suitable properties to avoid the adhesion of the viscera to the mesh. To prepare the double-sided structure, PGS/PCL was directly electrospun onto the PU film. This processing approach provided a final product with well-integrated layers as observed by a scanning electron microscope. Tensile test performed at the dry state of the samples showed that the dual mesh has the ability to elongate seven times more as compared with the commercially available counterparts, mimicking the native tissue properties. The degradation test carried out at physiological conditions revealed that PGS started to degrade within the first 15 days. in vitro studies with human umbilical vein endothelial cells demonstrated the double function of the meshes, in which PU layer did not allow cell adhesion, whereas PGS/PCL layer has the ability to support cell adhesion and proliferation. Therefore, the material developed in this study has the potential to be an alternative to the existing hernia mesh products.

中文翻译：

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设计一种具有可吸收纳米纤维层的新型双网片，作为腹部疝气治疗的潜在植入物。

在腹壁缺损较大的脐疝和切开疝的治疗中，通常首选双网。这些网通常由两个不可吸收层或不可吸收层与可吸收层组合而成，该可吸收层在缺陷修复后会在体内降解。双网格设计中最关键的一点是根据接收方站点的结构和要求生成相应的图层。我们在本文中开发了一种由两层组成的双网：由聚（癸二酸甘油酯/聚己内酯）（PGS / PCL）制成的纳米纤维层，用于支持腹壁缺损的愈合，以及由以下材料制成的不可降解的，非粘性的光滑层：聚碳酸酯聚氨酯（PU）具有适当的性能，可避免内脏粘附到网格上。要准备双面结构，PGS / PCL直接电纺到PU膜上。如通过扫描电子显微镜观察到的，这种加工方法提供了具有良好集成的层的最终产品。在样品的干燥状态下进行的拉伸试验表明，与市售的同类产品相比，双网具有拉长七倍的能力，模仿了天然组织的特性。在生理条件下进行的降解测试表明，PGS在开始的15天内开始降解。用人脐静脉内皮细胞进行的体外研究证明了网片的双重功能，其中PU层不允许细胞粘附，而PGS / PCL层具有支持细胞粘附和增殖的能力。所以，