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Synthesis, characterization, electrochemical behavior and antioxidant activity of new copper(II) coordination compounds with curcumin derivatives
Journal of Saudi Chemical Society ( IF 5.8 ) Pub Date : 2019-03-11 , DOI: 10.1016/j.jscs.2019.02.006
Mirela Călinescu , Mălina Fiastru , Daniela Bala , Constantin Mihailciuc , Ticuţa Negreanu-Pîrjol , Bogdan Jurcă

Five new copper(II) coordination compounds were prepared by template synthesis, using curcumin, 2-hydrazinobenzothiazole and metal salt (copper chloride, bromide, acetate and nitrate) in 1:2:1 and 1:2:2 molar ratio. The complexes were characterized by elemental and thermogravimetric analysis, IR, UV–Vis and mass spectroscopic methods and cyclic voltammetric studies. On the basis of physico-chemical measurements the following formulae have been assigned to the complexes: [Cu(H2L)(H2O)2]Cl2·H2O, [CuL]·H2O, [Cu(H2L)(H2O)Br]Br·5H2O, [Cu2L(H2O)4](NO3)2·2H2O and [Cu2(H2L)(NO3)4]·H2O, where H2L is the hydrazone ligand formed in the reaction conditions. Metal complexes were tested for antioxidant activity by photochemiluminescence and this activity was quantified by comparison with TROLOX®, as standard. The results show that all complexes are more potent antioxidant agents than curcumin.



中文翻译:

姜黄素衍生物的新型铜(II)配位化合物的合成,表征,电化学行为和抗氧化活性

通过模板合成,使用姜黄素,2-肼基苯并噻唑和金属盐(氯化铜,溴化物,乙酸盐和硝酸盐)以1:2:1和1:2:2的摩尔比合成了五种新的铜(II)配位化合物。通过元素和热重分析,IR,UV-Vis和质谱方法以及循环伏安法研究对复合物进行表征。根据理化测量结果,对这些配合物指定了以下公式:[Cu(H 2 L)(H 2 O)2 ] Cl 2 ·H 2 O,[CuL]·H 2 O,[Cu( H 2 L)(H 2 O)Br] Br·5H 2 O,[Cu 2 L(H 2 O)4](NO 32 ·2H 2 O和[Cu 2(H 2 L)(NO 34 ]·H 2 O,其中H 2 L是在反应条件下形成的配体。通过光化学发光测试了金属配合物的抗氧化活性,并通过与TROLOX®(作为标准品)进行比较来量化该活性。结果表明,所有复合物均比姜黄素更有效。

更新日期:2019-03-11
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