The reactions of a range of aromatic primary amines with pyridine-2-carboxaldehyde were reported, highlighting the effect of the substituents of the amine on the outcomes of the Schiff base reactions. The variant products of the Schiff base reactions were reacted with cis-[PtCl₂(DMSO)₂], generating platinum(II) complexes with PtCl₂(N^N) general formula. The ligands and platinum(II) complexes were identified and characterized by IR and NMR spectroscopic methods. Single crystal XRD offered structural confirmation for three of the organic compounds and two platinum complexes. The spectral, antimicrobial, DNA-binding and molecular docking of the platinum complexes were studied, highlighting the effect of the different functional group in the Schiff base ligands on their properties. In general, introducing the electron-withdrawing group nitro or acetyl in the 2-pyridyl Schiff base ligands, results in a red-shift in the absorption maxima of the platinum complex. In addition, the enhancement in the antimicrobial activities and the increase in the ct-DNA-binding affinity were also observed when the nitro or acetyl functional group is introduced to the Schiff base ligand in the platinum(II) complex.

报道了一系列芳族伯胺与吡啶-2-甲醛的反应，突出了胺取代基对席夫碱反应结果的影响。Schiff碱反应的变异产物与顺式[PtCl ₂（DMSO）₂ ]反应，生成与PtCl _2的铂（II）配合物（N ^ N）通用公式。通过IR和NMR光谱法鉴定并表征了配体和铂（II）配合物。单晶XRD为三种有机化合物和两种铂配合物提供了结构确认。研究了铂配合物的光谱，抗菌，DNA结合和分子对接，突出了席夫碱配体中不同官能团对其性能的影响。通常，在2-吡啶基席夫碱配体中引入吸电子基团硝基或乙酰基导致铂配合物的最大吸收红移。此外，