Aerobic exercise has been associated with hippocampal plasticity, both in healthy adults and in psychosis patients, but its impact on cortical regions remains unclear. The entorhinal cortex serves as a critical gateway for the hippocampus, and recent studies suggest that this region may also be impacted following an exercise regime. In order to investigate the effects of antipsychotic medications and exercise on the entorhinal cortex, female rats were chronically administered either olanzapine or vehicle and were either sedentary or had access to a running wheel for 9 weeks. Olanzapine-treated rats had decreased medial entorhinal cortical thickness compared to vehicle-treated rats. A statistically significant interaction was observed for layer II of the entorhinal cortex, with exercising rats having significantly greater thickness compared to sedentary rats in the vehicle group, but not the olanzapine group. Greater total entorhinal and lateral entorhinal cortical thickness was associated with greater average activity. In exercising rats, decreasing glucose intolerance was associated with larger total entorhinal and layer II cortical thickness. Lower fasting insulin levels were associated with greater total entorhinal, lateral entorhinal, and layer II cortical thickness. The relationship between increased activity and greater entorhinal cortical thickness was mediated by reduced fasting insulin, indicating that regulation of metabolic risk factors may contribute to impact of aerobic exercise on the entorhinal cortex. Aerobic exercise may be helpful in counteracting metabolic side effects of antipsychotic medications and managing these side effects may be key to promoting entorhinal cortical plasticity in patients treated with second-generation antipsychotic drugs.

在健康成年人和精神病患者中，有氧运动都与海马可塑性有关，但尚不清楚其对皮层区域的影响。内嗅皮层是海马的重要通道，最近的研究表明，该区域在运动后也可能受到影响。为了研究抗精神病药物和运动对内嗅皮层的影响，对雌性大鼠长期给予奥氮平或媒介物，久坐或久坐不动，或使用跑轮9周。与赋形剂治疗的大鼠相比，奥氮平治疗的大鼠的内嗅神经皮质厚度减少。在内嗅皮层的第二层观察到了统计学上显着的相互作用，与运动组中的久坐大鼠相比，运动大鼠的厚度显着增加，但奥氮平组则没有。总内嗅和外侧内嗅皮质总厚度越大，平均活性越高。在运动大鼠中，葡萄糖耐量降低与总内啡肽和II层皮质厚度增加有关。空腹胰岛素水平较低与总内嗅，侧内嗅和II层皮质厚度增加有关。空腹胰岛素的减少介导了活动增加和内嗅皮质厚度增加之间的关系，表明代谢风险因子的调节可能有助于有氧运动对内嗅皮质的影响。