The potential human health benefits of American cranberry (Vaccinium macrocarpon Ait.) leads to the popularity of its dietary supplements in the U.S. market. However, the qualities of the cranberry dietary supplements (CDSs) have never been carefully evaluated. In this study, the phenolic components in ten different CDSs were analyzed using ultra-performance liquid chromatography high-resolution mass spectrometry (UHPLC-HRMS). The study found quercetin and myricetin aglycones in most CDSs, but not in cranberry fruits, despite otherwise similar phenolic profiles between CDS and cranberry fruits in general. One supplement with high levels of B-type proanthocyanidins and non-cranberry flavonol rutin was determined to be adulterated by other botanical extracts. The CDSs only possessed 4% to 11% of the phenolic contents comparing to their claimed fresh cranberry equivalents, emphasizing the urgency of standardized product quality control and labelling for CDS manufacture and marketing.

中文翻译：

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使用 UHPLC-HRMS 分析蔓越莓膳食补充剂中的酚类成分

美国蔓越莓 (Vaccinium macrocarpon Ait.) 的潜在人类健康益处导致其膳食补充剂在美国市场广受欢迎。然而，蔓越莓膳食补充剂 (CDS) 的质量从未经过仔细评估。在本研究中，使用超高效液相色谱高分辨率质谱 (UHPLC-HRMS) 分析了 10 种不同 CDS 中的酚类成分。该研究在大多数 CDS 中发现了槲皮素和杨梅素苷元，但在蔓越莓果实中没有发现，尽管 CDS 和蔓越莓果实之间的酚类成分通常相似。一种含有高水平 B 型原花青素和非蔓越莓黄酮醇芦丁的补充剂被确定被其他植物提取物掺假。