Abstract A novel electrochemical sensor based on (3-aminopropyl)triethoxysilane (APTES) functionalized SiO2 supported Au nanoparticles and Nafion (Nf) as the protective membrane was fabricated for the electrochemical determination of H2O2 in contact lens-cleaning solution. The modification steps of glassy carbon working electrode (GCE) were evaluated by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The amperometric results showed that Nf/Au@SiO2-APTES/GCE sensor can be used to determine H2O2 in contact lens solutions with the linear ranges of 14–180 μM and 0.18–7.15 mM, excellent sensitivities of 2514.6 and 894.2 μA mM cm−2, and a low limit of detection (LOD) of 4.25 μM depending upon signal-to-noise ratio of 3. Nf/Au@SiO2-APTES/GCE exhibited excellent repeatability with relative standard deviation (RDS) of 2.66% and acceptable reproducibility with RSD of 3.35%. The sensor displayed reasonable selectivity in the presence of uric acid, dopamine, ascorbic acid, glucose, mannose, glycine, fructose, histidine, and arginine with RSD less than 2.5%. The fabricated Nf/Au@SiO2-APTES/GCE sensor has been successfully applied to detect H2O2 in contact lens cleaning solutions.

中文翻译：

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基于SiO2-APTES负载的Au纳米颗粒修饰玻碳电极的超灵敏非酶促过氧化氢传感器

摘要 基于（3-氨基丙基）三乙氧基硅烷（APTES）功能化的SiO2负载的Au纳米颗粒和Nafion（Nf）作为保护膜制备了一种新型电化学传感器，用于电化学测定隐形眼镜清洁液中的H2O2。通过电化学阻抗谱（EIS）和循环伏安法（CV）评估玻碳工作电极（GCE）的改性步骤。电流分析结果表明，Nf/Au@SiO2-APTES/GCE 传感器可用于测定隐形眼镜溶液中的 H2O2，线性范围为 14-180 μM 和 0.18-7.15 mM，灵敏度为 2514.6 和 894.2 μA mM cm− 2，检测下限 (LOD) 为 4.25 μM，取决于 3 的信噪比。 Nf/Au@SiO2-APTES/GCE 表现出出色的可重复性，相对标准偏差 (RDS) 为 2。66% 和可接受的重现性，RSD 为 3.35%。该传感器在尿酸、多巴胺、抗坏血酸、葡萄糖、甘露糖、甘氨酸、果糖、组氨酸和精氨酸存在下显示出合理的选择性，RSD 小于 2.5%。制造的 Nf/Au@SiO2-APTES/GCE 传感器已成功应用于检测隐形眼镜清洁液中的 H2O2。