当前位置: X-MOL 学术J. Nutr. Biochem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Resveratrol attenuates doxorubicin-induced cardiotoxicity in rats by up-regulation of vascular endothelial growth factor B.
The Journal of Nutritional Biochemistry ( IF 4.8 ) Pub Date : 2019-02-08 , DOI: 10.1016/j.jnutbio.2019.01.018
Wencong Tian 1 , Lei Yang 2 , Yuansheng Liu 3 , Jianxiang He 3 , Liang Yang 3 , Qiong Zhang 4 , Fei Liu 3 , Jing Li 3 , Jie Liu 3 , Shoichiro Sumi 5 , Yanna Shen 4 , Zhi Qi 6
Affiliation  

Doxorubicin (DOX) is a broad spectrum antitumor agent. However, its clinical utility is limited due to the well-known cardiotoxicity. Resveratrol (RSV) has been reported to exert cardioprotective effect in some cardiovascular diseases. In this study, we aimed to determine the effect of RSV on DOX-induced cardiotoxicity, and further explore the underlying mechanism in this process.Male Sprague-Dawley (SD) rats were randomly divided into four groups: CON, DOX, RSV, or DOX+RSV group (10 rats in each group). DOX treatment significantly decreased cardiac function, and increased the release of serum lactate dehydrogenase (LDH) and creatine kinase isoenzyme (CK-MB) in rat serum. Increased cell death and apoptosis of cardiomyocytes were also observed in DOX group in comparison with CON group. DOX treatment dramatically down-regulated expression of VEGF-B either in vivo or in vitro. In contrast, the combination of RSV and DOX markedly attenuated DOX-induced cardiotoxicity with the up-regulation of VEGF-B. Inhibition of VEGF-B by small interfering RNA (siRNA) abolished the protective effects of RSV on DOX-treated cardiomyocytes.Consequently,our findings indicated that RSV attenuates DOX-induced cardiotoxicity through up-regulation of VEGF-B.



中文翻译:

白藜芦醇通过上调血管内皮生长因子B减轻阿霉素诱导的大鼠心脏毒性。

阿霉素(DOX)是一种广谱抗肿瘤药。然而,由于众所周知的心脏毒性,其临床应用受到限制。据报道,白藜芦醇(RSV)在某些心血管疾病中具有心脏保护作用。在这项研究中,我们旨在确定RSV对DOX诱导的心脏毒性的影响,并进一步探索这一过程的潜在机制。雄性Sprague-Dawley(SD)大鼠随机分为4组:CON,DOX,RSV或DOX + RSV组(每组10只大鼠)。DOX处理可显着降低心脏功能,并增加大鼠血清中血清乳酸脱氢酶(LDH)和肌酸激酶同工酶(CK-MB)的释放。与CON组相比,DOX组还观察到细胞死亡和心肌细胞凋亡增加。体内体外。相反,RSV和DOX的组合显着减弱了DOX诱导的心脏毒性,并上调了VEGF-B的表达。小干扰RNA(siRNA)抑制VEGF-B消除了RSV对DOX处理的心肌细胞的保护作用。因此,我们的发现表明RSV通过上调VEGF-B减轻了DOX诱导的心脏毒性。

更新日期:2019-02-08
down
wechat
bug