To improve the utilization and achieve deep tumor penetration of nanocarriers, we developed a Janus nanocarrier by simply sputter Au on a mesoporous silica nanocarrier. Such Janus nanocarrier with an Au surface that could achieve efficient NIR propulsion, which are helpful for enhancing interaction with cells. The porous silicon sphere could immensely improve the loading efficiency. This nanocarrier could achieve deep tumor penetration by thermomechanical percolating cytomembranes and sequentially on-off controlled release. This system integrates the functions of active seeking, cytomembranes percolating, and on-off controlled release in one nanocarrier, which further improves the utilization of nanocarriers, and reduces the side effects of drugs. We believe that this approach provides new insight into multifunctional nanocarriers for deep tumor penetration and drug delivery.

为了提高利用率并实现纳米载体的深层肿瘤渗透，我们通过在中孔二氧化硅纳米载体上简单地溅射Au来开发了Janus纳米载体。这种具有Au表面的Janus纳米载体可以实现有效的NIR推进，这有助于增强与细胞的相互作用。多孔硅球可以极大地提高加载效率。该纳米载体可通过热机械渗滤细胞膜并顺序地开关控制释放来实现深入的肿瘤渗透。该系统在一个纳米载体中整合了主动寻找，细胞膜渗透和开关控制释放的功能，从而进一步提高了纳米载体的利用率，并减少了药物的副作用。