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The distinct transcriptomes of fast-twitch and slow-twitch muscles in Mongolian horses.
Comparative Biochemistry and Physiology D: Genomics & Proteomics ( IF 2.2 ) Pub Date : 2019-12-11 , DOI: 10.1016/j.cbd.2019.100649 Tugeqin Bao 1 , Haige Han 1 , Bei Li 1 , Yiping Zhao 1 , Gerelchimeg Bou 1 , Xinzhuang Zhang 1 , Ming Du 1 , Ruoyang Zhao 1 , Togtokh Mongke 1 , Laxima 1 , Wenqi Ding 1 , Zijie Jia 1 , Manglai Dugarjaviin 1 , Dongyi Bai 1
Comparative Biochemistry and Physiology D: Genomics & Proteomics ( IF 2.2 ) Pub Date : 2019-12-11 , DOI: 10.1016/j.cbd.2019.100649 Tugeqin Bao 1 , Haige Han 1 , Bei Li 1 , Yiping Zhao 1 , Gerelchimeg Bou 1 , Xinzhuang Zhang 1 , Ming Du 1 , Ruoyang Zhao 1 , Togtokh Mongke 1 , Laxima 1 , Wenqi Ding 1 , Zijie Jia 1 , Manglai Dugarjaviin 1 , Dongyi Bai 1
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Skeletal muscle is the largest organ system in the mammalian body and plays a key role in locomotion of horses. Fast and slow muscle fibers have different abilities and functions to adapt to exercises. To investigate the RNA and miRNA expression profiles in the muscles with different muscle fiber compositions on Mongolian horses. We examined the muscle fiber type population and produced deep RNA sequencing for different parts of skeletal muscles. And chose two of them with the highest difference in fast and slow muscle fiber population (splenius and gluteus medius) for comparing the gene expression profile of slow and fast muscle fiber types. We identified a total of 275 differentially expressed genes (DEGs), and 11 differentially expressed miRNAs (DEmiRs). In addition, target gene prediction and alternative splicing analysis were also performed. Significant correlations were found between the differentially expressed gene, miRNAs, and alternative splicing events. The result indicated that differentially expressed muscle-specific genes and target genes of miRNAs might co-regulating the performance of slow and fast muscle fiber types in Mongolian horses.
中文翻译：
蒙古马中快肌和慢肌的截然不同的转录组。
骨骼肌是哺乳动物体内最大的器官系统，在马的运动中起关键作用。快慢肌纤维具有不同的能力和功能以适应锻炼。要调查蒙古马中具有不同肌纤维组成的肌肉中RNA和miRNA的表达谱。我们检查了肌纤维类型种群，并针对骨骼肌的不同部位产生了深度RNA测序。并选择其中两个在快肌和慢肌纤维种群（脾脏和臀肌）中差异最大，以比较慢肌和快肌纤维类型的基因表达谱。我们确定了总共275个差异表达的基因（DEGs）和11个差异表达的miRNA（DEmiRs）。另外，还进行了靶基因预测和替代剪接分析。发现差异表达的基因，miRNA和其他剪接事件之间存在显着相关性。结果表明，差异表达的miRNA的肌肉特异性基因和靶基因可能会共同调节蒙古马慢速和快速肌纤维类型的性能。
更新日期：2019-12-11
中文翻译：
蒙古马中快肌和慢肌的截然不同的转录组。
骨骼肌是哺乳动物体内最大的器官系统，在马的运动中起关键作用。快慢肌纤维具有不同的能力和功能以适应锻炼。要调查蒙古马中具有不同肌纤维组成的肌肉中RNA和miRNA的表达谱。我们检查了肌纤维类型种群，并针对骨骼肌的不同部位产生了深度RNA测序。并选择其中两个在快肌和慢肌纤维种群（脾脏和臀肌）中差异最大，以比较慢肌和快肌纤维类型的基因表达谱。我们确定了总共275个差异表达的基因（DEGs）和11个差异表达的miRNA（DEmiRs）。另外，还进行了靶基因预测和替代剪接分析。发现差异表达的基因，miRNA和其他剪接事件之间存在显着相关性。结果表明，差异表达的miRNA的肌肉特异性基因和靶基因可能会共同调节蒙古马慢速和快速肌纤维类型的性能。
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