Environmentally responsive hydrogels are widely used in various applications. Facile synthesis of multiply stimuli-responsive hydrogels is necessary. Herein, a triple pH-, thermo- and ion-sensitive hydrogel, shorted as HSP, was synthesized by aqueous radical polymerization using L-serinyl acrylate as a monomer and PEG₁₈₀DMA as a crosslinker. The compositions and microstructures of HSP are characterized by FT-IR, ¹H NMR and SEM. The swelling ratio of HSP is the lowest at pH = 3.0 while increases sharply far away from this pH value. Meanwhile, HSP expands with elevated temperatures or ionic strengths, and reaches a plateau when they above 60 °C or 3.0 mol/L, respectively. In addition, these swelling processes are reversible under alternative changing in extern stimuli, and these cycles can be repeated at least 5 times. Furthermore, the release of sodium salicylate can be easily mediated by pH values, temperatures and ion concentrations, all above indicating that HSP is a promising material for controlled drug delivery.

对环境敏感的水凝胶广泛用于各种应用中。容易合成多种刺激反应性水凝胶是必要的。在本文中，通过使用丙烯酸L-丝氨酰丙烯酸酯作为单体并且使用PEG ₁₈₀ DMA作为交联剂的水性自由基聚合反应合成了三重pH敏感，热敏感和离子敏感的水凝胶，称为HSP 。HSP的组成和微观结构的特征在于FT-IR，¹1 H NMR和SEM。HSP的溶胀率在pH = 3.0时最低，而远离此pH值则急剧增加。同时，HSP随着温度或离子强度的升高而膨胀，并且当它们分别高于60°C或3.0 mol / L时达到平稳。另外，在外部刺激的交替变化下，这些膨胀过程是可逆的，并且这些循环可以重复至少5次。此外，水杨酸钠的释放可以很容易地通过pH值，温度和离子浓度来介导，所有这些表明HSP是用于控制药物输送的有前途的材料。