In this study, a series of Er³⁺/Yb³⁺ co-doped Ca–Mg–Si glasses were prepared via the containerless processing. Phase composition and luminescent properties of the prepared materials were investigated through XRD and spectrometry, and bioactivity, biocompatibility and cytotoxicity were evaluated. The XRD patterns indicated that akermanite (AKT) ceramic powders were completely transformed into the glassy phase (AKT-G, EYA) through the containerless processing, which exhibit upconversion luminescence, and the luminescence intensity increased with the increase of the doping amount of Er³⁺ and Yb³⁺. High amount of Yb³⁺ doping and existence of Ca²⁺ in glasses resulted in more intensive red-light emission. The SEM observation, combined with EDS analysis, and cell culture experiments showed that the as-prepared glasses were nontoxic, biocompatible and bioactive. All these results demonstrated that the containerless processing is a facile method for preparing homogeneous luminescent bioactive glasses. Furthermore, this luminescent Ca–Mg–Si glasses may be used as bone implant materials to study the in vivo distribution of degradation products of bone implants, which may be of great significance for the development and clinical application of new bone grafting materials.

在这项研究中，通过无容器加工制备了一系列Er ³⁺ / Yb ³⁺共掺杂的Ca-Mg-Si玻璃。通过X射线衍射和光谱法研究了所制备材料的相组成和发光性能，并评估了其生物活性，生物相容性和细胞毒性。X射线衍射图谱表明，钙钛矿（AKT）陶瓷粉通过无容器处理完全转变为玻璃相（AKT-G，EYA），呈现上转换发光，发光强度随着Er ³掺杂量的增加而增大。⁺和Yb ³⁺。大量的Yb ³⁺掺杂和Ca ^2+的存在眼镜中的红色导致更强烈的红光发射。SEM观察，EDS分析和细胞培养实验表明，所制备的玻璃无毒，具有生物相容性和生物活性。所有这些结果表明，无容器加工是制备均质发光生物活性玻璃的简便方法。此外，这种发光的Ca–Mg–Si玻璃可用作骨植入物材料，以研究骨植入物降解产物的体内分布，这对于新型骨移植材料的开发和临床应用可能具有重要意义。