The study presents the use of a continuous crystallization device that can be directly incorporated into flow chemistry setups. Inside this device spontaneous nucleation and growth of organic molecules are controlled and maintained, using Aspirin as model molecule. The identification of the optimal crystallization scenario is discussed in view of the chemical stability of Aspirin and based on the determination of the solubility and the metastable zone width corresponding to the presented experimental setups. Physicochemical analyses combined with heat transfer modeling of the solution whilst flowing through a capillary placed inside a thermostated water bath provide the desired cooling profile and hence the degree of supersaturation along the system. The crystalline quality and stability of the crystalline output is evidenced for two different pump setups having distinguished flow patterns to show the independence on the flow stability, an important parameter for the success rate of the complete reaction scheme and in the perspective of operation scale-up. Reproducible output of material with narrow size distributions is obtained throughout all experiments.

该研究提出了一种连续结晶装置的使用，该装置可以直接并入流化学装置中。在该装置内部，使用阿司匹林作为模型分子，可控制和维持有机分子的自发成核和生长。考虑到阿司匹林的化学稳定性，并根据与提出的实验装置相对应的溶解度和亚稳区宽度的确定，讨论了最佳结晶方案的确定。物理化学分析与溶液的热传递模型相结合，同时流经放置在恒温水浴内部的毛细管，可提供所需的冷却曲线，并因此提供沿系统的过饱和度。两种不同泵设置的结晶质量和结晶输出的稳定性得到了证明，这两种泵具有明显的流型，显示出流稳定性的独立性，而流稳定性是完整反应方案成功率的重要参数，并且在放大操作的范围内。在所有实验中，均获得了具有窄尺寸分布的可重现的材料输出。