Kinetic parameters of phenyl isocyanate–monoalcohol reactions has been studied using a microreactor system. The monoalcohol components were propan-1-ol, butan-1-ol, propan-2-ol and butan-2-ol. The reactions were conducted in alcohol/THF mixed solvent under pseudo-first-order circumstances at various temperatures. The reaction mixtures were analyzed by off-line HPLC. Reaction rate constants and apparent activation energies have been determined with good precision. The reaction rate constants were higher for the primary alcohols than for the secondary alcohols. Higher apparent activation energy was found for the secondary alcohols compared to the primary ones. The applied technique provides a simple way to study the effects of various factors (e.g. structure of the isocyanate and the alcohol, temperature, solvents, concentration of reagents, catalysis) on the kinetics of the isocyanate–alcohol reactions.

已使用微反应器系统研究了异氰酸苯酯一元醇反应的动力学参数。一元醇成分为丙-1-醇，丁-1-醇，丙-2-醇和丁-2-醇。该反应在拟一级反应条件下的醇/ THF混合溶剂中于各种温度下进行。通过离线HPLC分析反应混合物。已经确定了反应速率常数和表观活化能。伯醇的反应速率常数高于仲醇。发现仲醇比伯醇具有更高的表观活化能。应用的技术为研究各种因素（例如异氰酸酯和醇的结构，温度，溶剂，试剂浓度，