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On-chip mixing of liquids with swap structures written by two-photon polymerization
Microfluidics and Nanofluidics ( IF 2.8 ) Pub Date : 2019-12-06 , DOI: 10.1007/s10404-019-2309-8
Martin Oellers , Frieder Lucklum , Michael J. Vellekoop

A fluidic micromixer realized by two-photon polymerization writing is embedded in a predefined microchannel. The micromixer consists of a 3D defined channel system which swaps incoming fluid streams, resulting in laminar alternating streams consisting of the two liquids to be mixed. Due to the shortened diffusion length, mixing times are reduced dramatically to 50 ms or lower. The structure is designed in such a way that the fluidic resistance in each swapper channel is balanced, yielding equal distribution of the alternating streams. The mixer element has a total size of about \(225\times 100\times 50\,\upmu \hbox {m}^{3}\), fitting exactly in a prefabricated microchannel. The structure is strongly anchored in the channel so that it can handle high flow rates of up to 100 \(\upmu \text {L/min}\) (corresponding to an average flow velocity of \(400\,\text {mm/s}\)). A benefit of the fabrication method is the short processing time. The writing of one mixer element takes less than \(30\,\text {s}\), so that a whole wafer can be processed in typically less than one hour.



中文翻译:

具有双光子聚合作用的具有交换结构的液体的片上混合

通过双光子聚合写入实现的流体微混合器被嵌入到预定的微通道中。微型混合器由3D定义的通道系统组成,该系统交换进入的流体流,从而形成由两种待混合液体组成的层流交替流。由于缩短了扩散长度,混合时间大大减少到50毫秒或更短。该结构的设计方式使每个交换通道中的流体阻力达到平衡,从而产生交替分布的均等流。混合器元素的总大小约为\(225×100×50 \,\ upbox \ hbox {m} ^ {3} \),正好适合于预制的微通道。该结构牢固地固定在通道中,因此可以处理高达100 \(\ upmu \ text {L / min} \)的高流速 (对应于\(400 \,\ text {mm / s} \}的平均流速)。该制造方法的优点是处理时间短。写入一个混合器元素所需的时间少于\(30 \,\ text {s} \),因此整个晶圆通常可以在不到一小时的时间内进行处理。

更新日期:2019-12-06
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