To reduce the long-term side effects of permanent metallic stents, a new generation of cardiovascular stents called "biodegradable stents" is being extensively developed. Zinc has been considered as a promising candidate material for biodegradable cardiovascular stents due to its excellent biocompatibility and appropriate biodegradability. However, weak mechanical properties limit its further clinic application. In this study, hot extruded pure Zn and Zn-0.02 Mg alloy were prepared. Compared with pure Zn, Zn-0.02 Mg alloy showed more homogeneous microstructure, much smaller grain size and higher mechanical strength. Zn-0.02 Mg alloy presented uniform corrosion morphologies during the immersion process, and its corrosion rates was higher than that of pure Zn. Hemocompatibility results showed that the Zn-based alloy had extremely low hemolysis rate (0.74 ± 0.15%) and strong inhibitory effect on blood coagulation, platelet adhesion and aggregation. Zn-0.02 Mg alloy also exhibited excellent cytocompatibility. Its extracts could significantly promote the proliferation of endothelial cells. Moreover, the antibacterial activities of the Zn-based alloy were demonstrated by spread plate assay, live/dead viability assay and bacterial morphology observation. These results indicate that the extruded Zn-0.02 Mg alloy has a potential in biodegradable cardiovascular stents.

中文翻译：

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Zn-Mg合金的系统进化可能是为可生物降解的心血管支架而开发的。

为了减少永久金属支架的长期副作用，正在广泛开发新一代的称为“生物可降解支架”的心血管支架。锌因其出色的生物相容性和适当的生物降解性而被认为是可生物降解的心血管支架的有前途的候选材料。但是，较弱的机械性能限制了其进一步的临床应用。在这项研究中，制备了热挤压纯锌和Zn-0.02 Mg合金。与纯锌相比，Zn-0.02 Mg合金具有更均匀的组织，更小的晶粒尺寸和更高的机械强度。Zn-0.02 Mg合金在浸没过程中呈现出均匀的腐蚀形态，其腐蚀速率高于纯Zn。血液相容性结果表明，锌基合金的溶血率极低（0.74±0.15％），对凝血，血小板粘附和聚集的抑制作用强。Zn-0.02 Mg合金也表现出优异的细胞相容性。其提取物可以显着促进内皮细胞的增殖。此外，通过铺板分析，活/死活力分析和细菌形态学观察证明了锌基合金的抗菌活性。这些结果表明，挤压的Zn-0.02 Mg合金在可生物降解的心血管支架中具有潜力。其提取物可以显着促进内皮细胞的增殖。此外，通过铺板分析，活/死活力分析和细菌形态学观察证明了锌基合金的抗菌活性。这些结果表明，挤压的Zn-0.02 Mg合金在可生物降解的心血管支架中具有潜力。其提取物可以显着促进内皮细胞的增殖。此外，通过铺板分析，活/死活力分析和细菌形态学观察证明了锌基合金的抗菌活性。这些结果表明，挤压的Zn-0.02 Mg合金在可生物降解的心血管支架中具有潜力。