A drying method that can effectively remove residual solvents from chloroform-induced amorphous paclitaxel was developed. Simple rotary evaporation with alcohol (methanol or ethanol) pretreatment was sufficient to remove residual chloroform and alcohol concentrations below the ICH limits (60 ppm for chloroform, 3,000 ppm for methanol, and 5,000 ppm for ethanol). In addition, SEM analysis and ultrasonic treatment showed that residual solvent removal is related to the porous structure of the sample due to the high vapor pressure of the chloroform-alcohol mixture and the hydrogen bonding between chloroform and alcohol.

中文翻译：

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乙醇预处理无定形紫杉醇中残留氯仿的去除

开发了一种可以有效去除氯仿诱导的无定形紫杉醇中残留溶剂的干燥方法。使用酒精（甲醇或乙醇）预处理的简单旋转蒸发足以去除残留的氯仿和酒精浓度低于 ICH 限值（氯仿为 60 ppm，甲醇为 3,000 ppm，乙醇为 5,000 ppm）。此外，SEM分析和超声处理表明，由于氯仿-醇混合物的高蒸气压以及氯仿和醇之间的氢键作用，残留溶剂的去除与样品的多孔结构有关。